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SYVN1
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Plasma cells, Hepatocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-698)
Interaction
Homodimer (PubMed:16289116). Interacts with p53/TP53 (PubMed:17170702). Interacts with HTT (PubMed:17141218). Component of the HRD1 complex, which comprises at least SYNV1/HRD1, DERL1/2, FAM8A1, HERPUD1/HERP, OS9, SEL1L and UBE2J1 (PubMed:16289116, 16186509, 18264092, 26471130, 28827405). FAM8A1 is stabilized by interaction with SYNV1, which prevents its proteasomal degradation. OS9 and UBE2J1 recruitment to the complex may be mediated by SEL1L (PubMed:28827405). SYNV1 assembles with SEL1L and FAM8A1 through its transmembrane domains, but interaction with its cytoplasmic domain is required to confer stability to FAM8A1 and enhance recruitment of HERPUD1 (PubMed:28827405). The HRD1 complex also associates with VIMP and may transfer misfolded proteins from the endoplasmic reticulum to VCP (PubMed:16289116). May form a complex with ERLEC1; HSPA5; OS9 AND SEL1L (PubMed:18502753, 18264092). Interacts with VCP (PubMed:16289116, 16186510). Interacts with UBXN6 (PubMed:18656546). Interacts with BAG6 (PubMed:21636303). Interacts with NFE2L1 (By similarity). Interacts (via N-terminus) with components of the pre-B cell receptor, including IGLL1 and VPREB1 (By similarity). Interacts with CREB3L3; this interaction leads to CREB3L3 ubiquitination and proteasomal degradation (By similarity).
Molecular function
Transferase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF, FC, IP
- Mouse Anti-SYVN1 Recombinant Antibody (clone SL-1) (HPAB-0186-LSX)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Mouse Anti-SYVN1 Recombinant Antibody (clone SL-1); scFv Fragment (HPAB-0186-LSX-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
- Mouse Anti-SYVN1 Recombinant Antibody (clone SL-1); Fab Fragment (HPAB-0186-LSX-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.