TAK1

Enables JUN kinase kinase kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signal transduction; morphogenesis of an epithelium; and response to bacterium. Located in cytoplasm. Is expressed in adult Malpighian tubule and organism. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).