Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Glandular and luminal cells, Basal keratinocytes, Suprabasal keratinocytes, T-cells, Endometrial ciliated cells, Macrophages)
Low immune cell specificity
Cell line enhanced (GAMG, Karpas-707, REH, U-266/84)
Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.
DNA-binding, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase
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For Research Use Only. Not For Clinical Use.