Rabbit Anti-TNFAIP3 Recombinant Antibody (clone R06-9B2) (CAT#: VS3-FY1908)

• Immunogen
• Synthetic peptide of human TNFAIP3

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human TNFAIP3

• Species Reactivity
• Human

• Clone
• R06-9B2

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 90 kDa, while the observed molecular weight stands at 82 kDa.

• Related Disease
• Human lung cancer

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200

• Alternative Names
• TNF Alpha Induced Protein 3; Putative DNA-Binding Protein A20; OTU Domain-Containing Protein 7C; Zinc Finger Protein A20; OTUD7C; Tumor Necrosis Factor, Alpha-Induced Protein 3; Tumor Necrosis Factor, Alpha Induced Protein 3; Tumor Necrosis Factor Alpha-Induced Protein 3

• Gene ID
• 7128

• UniProt ID
• P21580

• Sequence Similarities
• Belongs to the peptidase C64 family.

• Cellular Localization
• Cytoplasm, Lysosome, Nucleus

• Post Translation Modifications
• Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production.
  It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.
  (P21580-TNAP3_HUMAN)
  Ubiquitination at Lys541, Lys621, Lys643, Lys676, and Lys722 (NX_P21580 [NX_P21580-1])
  Modification sites at PhosphoSitePlus (P21580)
  Glycosylation from GlyGen (P21580) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005267176.1; XP_011534397.1; XP_011534398.1; XP_024302300.1; XP_024302301.1

• Function
• Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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