Rabbit Anti-TNFAIP3 Recombinant Antibody (clone R06-9B2) (CAT#: VS3-FY1908)
Clone R06-9B2 is a rabbit recombinant monoclonal antibody that effectively recognizes human TNFAIP3. The antibody is recommended for detection of TNFAIP3 protein by WB, IHC-F, IHC-P, ICC/IF. The TNFAIP3 antibody is guaranteed for western blot analysis of TNFAIP3 in Hela lysates and immunohistochemistry analysis of paraffin-embedded human lung cancer tissue.
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WB
Figure 1 Anti-TNFAIP3 Antibody (VS3-FY1908) in WB.
The TNFAIP3 expression in Hela lysates were detected using the anti-TNFAIP3 by western blot assay.
IHC
Figure 2 Anti-TNFAIP3 Antibody (VS3-FY1908) in IHC.
Immunohistochemistry staining of paraffin-embedded human lung cancer tissue using the anti-TNFAIP3 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for.
Specifications
- Immunogen
- Synthetic peptide of human TNFAIP3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TNFAIP3
- Species Reactivity
- Human
- Clone
- R06-9B2
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 90 kDa, while the observed molecular weight stands at 82 kDa.
- Related Disease
- Human lung cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- TNF Alpha Induced Protein 3; Putative DNA-Binding Protein A20; OTU Domain-Containing Protein 7C; Zinc Finger Protein A20; OTUD7C; Tumor Necrosis Factor, Alpha-Induced Protein 3; Tumor Necrosis Factor, Alpha Induced Protein 3; Tumor Necrosis Factor Alpha-Induced Protein 3
- Gene ID
- 7128
- UniProt ID
- P21580
- Sequence Similarities
- Belongs to the peptidase C64 family.
- Cellular Localization
- Cytoplasm, Lysosome, Nucleus
- Post Translation Modifications
- Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production.
It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.
(P21580-TNAP3_HUMAN)
Ubiquitination at Lys541, Lys621, Lys643, Lys676, and Lys722 (NX_P21580 [NX_P21580-1])
Modification sites at PhosphoSitePlus (P21580)
Glycosylation from GlyGen (P21580) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005267176.1; XP_011534397.1; XP_011534398.1; XP_024302300.1; XP_024302301.1
- Function
- Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4021z | Mouse Anti-TNFAIP3 Recombinant Antibody (clone 24G10) | WB, FC, ICC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-2068CT | Recombinant Mouse anti-Human TNFAIP3 Monoclonal antibody (60B537) | FC, IHC-P, WB | |
| MRO-1508-CN | Rabbit Anti-TNFAIP3 Recombinant Antibody (clone CBACN-554) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-2234-CN | Rabbit Anti-TNFAIP3 Polyclonal Antibody (MRO-2234-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-CJ778 | Rabbit Anti-TNFAIP3 Recombinant Antibody (VS3-CJ778) | WB, ICC, IF, IHC, FC | Rabbit IgG |
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