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TRIM22
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (B-cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, HSkMC, TIME)
Interaction
Homotrimer (PubMed:17156811). (Microbial infection) Interacts with HIV-1 Gag polyprotein; this interaction seems to reduce gag production or virus budding. (Microbial infection) Interacts with EMCV protease 3C; this interaction leads to viral protease ubiquitination.
Molecular function
Repressor, Transferase
More Types Infomation
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC
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For Research Use Only. Not For Clinical Use.