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VAMP2
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with BVES and STX4 (By similarity). Interacts with VAPA and VAPB. Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651). Forms a complex with WDFY2 and PRKCZ (PubMed:17313651). Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP. Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (By similarity). Interacts with PICALM (PubMed:22118466, PubMed:21808019). Interacts with alpha-synuclein/SNCA (PubMed:20798282). Interacts with STX3 (By similarity).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC
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- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, FC, IP
- Rabbit Anti-VAMP2 Recombinant Antibody (clone JM11-00) (MRO-1570-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP, IF, FC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
- Recombinant Mouse Anti-VAMP2 Antibody (clone 5A2C7) (VS3-FY1533)
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- Type: Mouse IgG1
- Application: ELISA, IHC, FC
- Chicken Anti-VAMP2 Polyclonal IgY (BRD-0622MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ICC, WB
- Guinea pig Anti-VAMP2 Recombinant Antibody (VS-0223-WK68) (VS-0223-WK68)
-
- Derivation: Guinea pig
- Species Reactivity: Mouse, Rat, Human, Hamster
- Type: Guinea pig IgG
- Application: WB, IP, ICC, IHC, IHC-P
- Rabbit Anti-VAMP2 Recombinant Antibody (VS-0223-WK67) (VS-0223-WK67)
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- Derivation: Rabbit
- Species Reactivity: Mouse, Rat, Human, Hamster
- Type: Rabbit IgG
- Application: WB, IP, ICC, IHC, IHC-P
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