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WRN
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3->5 exonuclease activity towards double-stranded DNA with a 5-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Oligodendrocytes, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer, and homooligomer (PubMed:11863428, PubMed:18596042, PubMed:20159463). May exist as homodimer, homotrimer, homotetramer and/or homohexamer (PubMed:11863428, PubMed:18596042, PubMed:20159463). Homotetramer, or homohexamer, when bound to DNA (PubMed:11863428, PubMed:18596042, PubMed:20159463). Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1, PCNA and SUPV3L1 (PubMed:12704184, PubMed:17961633). Interacts with PML (isoform PML-4) (PubMed:21639834). Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites (PubMed:27063109). Interacts with RECQL5; this interaction stimulates WRN helicase activity on DNA fork duplexes (PubMed:23180761).
Molecular function
DNA-binding, Exonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-WRN Recombinant Antibody (clone 18H4) (MOB-3703z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, ICC, IF
- Recombinant Mouse Anti-Human WRN Antibody (MOB-1788MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
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For Research Use Only. Not For Clinical Use.