The tenth fibronectin type III domain (10Fn3) that bound Proprotein convertase subtilisin kexin-9 (PCSK9) was isolated from the library using phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1.2 nM) for Proprotein convertase subtilisin kexin-9 (PCSK9) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H31 | Human Anti-PCSK9 Recombinant Antibody (TAB-H31) | FC, IP, ELISA, Neut, FuncS, IF, IHC | Human IgG2, λ |
TAB-0953CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0953CL-S(P)) | ELISA | Human scFv |
TAB-0954CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0954CL-S(P)) | WB | Human scFv |
TAB-0955CL-S(P) | Mouse Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0955CL-S(P)) | WB | Mouse scFv |
TAB-0959CL-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (TAB-0959CL-S(P)) | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H10 | Anti-Human PCSK9 Recombinant Antibody (Bococizumab) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG2 - kappa |
TAB-H59 | Anti-Human PCSK9 Recombinant Antibody (Ralpancizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 - kappa |
TAB-0957CL | Anti-Human PCSK9 Recombinant Antibody (h7F8) | ELISA | Humanized antibody |
TAB-0958CL | Anti-Human PCSK9 Recombinant Antibody (h7F8ml2) | ELISA | Humanized antibody |
TAB-0020CL-F(E) | Anti-Human PCSK9 Recombinant Antibody Fab Fragment (LPD1282/LPD1462 {i.e., antibody 1 F11)) | LDL-c uptake assay | Humanized Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-294 | Human Anti-PCSK9 Recombinant Antibody (clone mAb1); scFv Fragment | WB, Block, FuncS | Human scFv |
HPAB-1591-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1591-FY-F(E)) | ELISA, Inhib | Human Fab |
HPAB-1592-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1592-FY-F(E)) | ELISA, Inhib | Human Fab |
HPAB-0479-YJ-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (HPAB-0479-YJ-S(P)) | ELISA, Inhib, FuncS | Human scFv |
HPAB-0480-YJ-S(P) | Human Anti-PCSK9 Recombinant Antibody; scFv Fragment (HPAB-0480-YJ-S(P)) | ELISA, Inhib, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-294 | Human Anti-PCSK9 Recombinant Antibody (clone mAb1); Fab Fragment | WB, Block, FuncS | Human Fab |
PFBL-670 | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (PFBL-670) | WB, FuncS | Human Fab |
PFBL-671 | Mouse Anti-PCSK9 Recombinant Antibody (clone mAb J16); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
PFBL-672 | Human Anti-PCSK9 Recombinant Antibody (clone CBL36Q); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0234-YC-F(E) | Mouse Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-0234-YC-F(E)) | ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-676 | Human Anti-PCSK9 Recombinant Antibody (PABL-676) | WB, FuncS | Human IgG |
PABL-677 | Mouse Anti-PCSK9 Recombinant Antibody (clone mAb J16) | WB, ELISA, FuncS | Mouse IgG |
PABL-678 | Human Anti-PCSK9 Recombinant Antibody (clone CBL21Q) | ELISA, WB | Human IgG |
PABC-196 | Human Anti-PCSK9 Recombinant Antibody (clone J16) | IF, IP, WB, ELISA | Human IgG |
HPAB-0240-WJ | Mouse Anti-PCSK9 Recombinant Antibody (HPAB-0240-WJ) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0956CL | Anti-Human PCSK9 Recombinant Antibody (m7F8) | ELISA | |
TAB-0960CL | Anti-Human PCSK9 Recombinant Antibody (Ab1) | ELISA | Rabbit mAb |
TAB-0956CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (m7F8) | ELISA | |
TAB-0960CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (Ab1) | ELISA | Rabbit mAb |
TAB-0956CL-F(E) | Anti-Human PCSK9 Recombinant Antibody Fab Fragment (m7F8) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0080CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (PKE2) | FuncS, Inhib, FC, WB | Single domain antibody |
TAB-0081CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (PKF8) | FuncS, Inhib, FC, WB | Single domain antibody |
TAB-0082CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (PKG1) | FuncS, Inhib, FC, WB | Single domain antibody |
TAB-0083CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (P1.70) | FuncS, Inhib, FC, WB | Single domain antibody |
TAB-0084CL-VHH | Anti-Human PCSK9 VHH Single Domain Antibody (PKE1) | FuncS, Inhib, FC, WB | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1826CQ | Recombinant Human Anti-PCSK9 Antibody, Unconjugated | Neut | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2618 | Hi-Affi™ Recombinant Rabbit Anti-PCSK9 Monoclonal Antibody (DS2618AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-758 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody (Lodelcizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H10 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody (Bococizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
AFC-TAB-H59 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody (Ralpancizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-H31 | Afuco™ Anti-PCSK9 Recombinant Antibody (AFC-TAB-H31), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, λ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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