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PCSK9

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PCSK9 (proprotein convertase subtilisin 9) is an enzyme encoded by the PCSK9 gene on the human chromosome 1, which is the 9th member of the proprotein convertase family that activates other proteins. Similar genes (orthologs) have been found in many species. Like many proteins, PCSK9 is inactive when first synthesized. Because a portion of the peptide chain blocks its activity, proprotein convertase removes this portion to activate the enzyme. The PCSK9 gene also contains one of 27 loci associated with an increased risk of coronary artery disease. PCSK9 is commonly expressed in many tissues and cell types. PCSK9 binds to low-density lipoprotein particle (LDL) receptors, which typically transport 3,000 to 6,000 fat molecules (including cholesterol) in the extracellular fluid. The LDL receptor (LDLR) binds on the liver and other cell membranes and initiates LDL particles to enter cells from the extracellular fluid, thereby lowering LDL particle concentration. If PCSK9 is blocked, more LDLR is recycled and present on the cell surface to remove LDL-particles from the extracellular fluid. Therefore, blocking PCSK9 can reduce blood LDL-particle concentration. PCSK9 is of medical importance because it plays a role in lipoprotein homeostasis. Agents that block PCSK9 can reduce LDL particle concentration. The FDA approved the PCSK9 inhibitor Alirocumab (trade name Praluent) on July 24, 2015. It is a human monoclonal antibody that is a novel anti-cholesterol drug and is used in high-cholesterol second-line treatment of adult cholesterol that is not controlled by diet and statin therapy, and is the first FDA approved drug. U.S. Food and Drug Administration approval depends on the completion of further clinical trials to better determine efficacy and safety.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
FC, Neut, Biosensors, FuncS
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Scaffold Name:
10-FnIII
Target:
Proprotein convertase subtilisin kexin-9 (PCSK9)
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
10-FnIII
Target:
Proprotein convertase subtilisin kexin-9 (PCSK9)
Species Reactivity:
Human
Derivation:
mRNA Display
Derivation:
Human
Species Reactivity:
Human
Application:
ELISA, WB, Neut
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB
Derivation:
human
Species Reactivity:
Human
Type:
IgG2 - lambda
Application:
FC, IP, ELISA, Neut, FuncS, IF, IHC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, BL, FuncS
Type:
Human antibody
Type:
Human antibody
Application:
WB
Type:
Human antibody
Application:
WB
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, FC, IP, ELISA, Neut, FuncS, IF
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