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PCSK9

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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Derivation:
human
Species Reactivity:
Human
Type:
IgG2 - lambda
Application:
FC, IP, ELISA, Neut, FuncS, IF, IHC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, FC, IP, ELISA, Neut, FuncS, IF
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Scaffold Name:
10-FnIII
Target:
Proprotein convertase subtilisin kexin-9 (PCSK9)
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
10-FnIII
Target:
Proprotein convertase subtilisin kexin-9 (PCSK9)
Species Reactivity:
Human
Derivation:
mRNA Display
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, BL, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, BL, FuncS
Derivation:
Human
Species Reactivity:
Human
Application:
ELISA, WB, Neut
Type:
Human antibody
Type:
Human antibody
Application:
WB
Type:
Human antibody
Application:
WB
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FuncS
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