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PCSK9

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The human proprotein convertase subtilisin 9 (PCSK9) gene is located on the short arm of chromosome 1 (1p32.3). PCSK9 is the ninth member of the proproteinase subtilisin family and is soluble endogenous serine. Protease is composed of the N-terminal signal peptide sequence, catalytic domain, prodomain and cysteine-rich C-terminal domain, which is mainly synthesized in the hepatic endoplasmic reticulum, in the intestine, kidney, etc. The site also has a low level of expression.
Under normal circumstances, LDL-C particles form a complex by binding to the low-density lipoprotein cholesterol receptor (LDLR) on the surface of the hepatocyte membrane and are endocytosed into hepatocytes. Subsequently, LDL-C particles are degraded in lysosomes, LDLR can be freely returned to the cell surface, combining the LDL-C particles in the rest of the cycle. While PCSK9 binds to the LDL-LDLR complex, this complex will be degraded together in the lysosome, reducing the amount of recyclable LDLR, reducing LDL-C clearance, and increasing plasma LDL-C levels. PCSK9 is a novel proprotein convertase that enhances the ability of hepatocytes to degrade low-density lipoprotein (LDLR) by gene-derived mutations and inhibits the clearance of lipids such as low-density lipoprotein cholesterol (LDL-C), resulting in increased serum levels, which in turn leads to high LDL-C and increases the risk of atherosclerosis.
PCSK9 inhibitors reduce circulating LDL-C levels by blocking PCSK9 degradation of LDLR. According to their different mechanisms of action, they can be divided into three categories. (1) antisense oligonucleotides or small interfering RNA (siRNA): inhibition of PCSK9 synthesis by gene silencing; (2) monoclonal antibody or mimetic antibody protein: direct inhibition of PCSK9 protein binding to LDLR; (3) affect Small peptides in the catalytic site of PCSK9 protein: these peptides can bind to the catalytic site of PCSK9 protein to cause allosteric transformation, which in turn affects the binding of PCSK9 protein to LDLR.

Derivation:
human
Species Reactivity:
Human
Type:
IgG2 - lambda
Application:
FC, IP, ELISA, Neut, FuncS, IF, IHC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
WB, FC, IP, ELISA, Neut, FuncS, IF
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, Neut
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, BL, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, Neut
Type:
Human antibody
Type:
Human antibody
Application:
WB
Type:
Human antibody
Application:
WB
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Derivation:
Humanized
Species Reactivity:
Rhesus
Type:
Humanized antibody
Application:
ELISA
Type:
Human antibody
Application:
SDS-PAGE, ELISA, FC
Type:
Rabbit mAb
Application:
ELISA
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
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