Mouse Anti-MICA/MICB Recombinant Antibody (clone 6E1) (CAT#: PABC-250)
This product is a recombinant Mouse antibody that can recognize MICA/B.
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Activ
Figure 1 Mouse Anti-MICA/MICB Antibody (clone 6E1) in Activ.
MICA immune complex formed with anti-MICA antibody clone 6E1 directly activates NK cells. a C1R-MICA*002 cell killing was assessed by co-culturing C1R-MICA*002 cell line with primary NK cells. The NK cells were pretreated with MICA-ECD alone, MICA-IC preformed with 6E1 (hIgG1, wildtype), MICA-IC preformed with 6E1 Fc effectorless mutant (hIgG1, N297G), or no treatment; NK cell killing of parental C1R cell line was used for comparison.
Du, C., Bevers, J., Cook, R., Lombana, T. N., Rajasekaran, K., Matsumoto, M., ... & Ye, Z. (2019). MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner. Journal for immunotherapy of cancer, 7(1), 1-13.
Specifications
- Immunogen
- MIC protein(s)
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG
- Specificity
- Human MICA/MICB
- Species Reactivity
- Human
- Clone
- 6E1
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MICA; MICB; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B
- Gene ID
- 100507436
- UniProt ID
- Q29983
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-250 | Mouse Anti-MICA/MICB Recombinant Antibody (clone 6E1); Fab Fragment | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-250 | Mouse Anti-MICA/MICB Recombinant Antibody (clone 6E1); scFv Fragment | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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