High Throughput Antibody Production Services assist AI-driven Lead Discovery

Creative Biolabs' is building a next-generation high-throughput antibody production technology for various artificial intelligence (AI)-derived antibody types and works with our customers to promote the efficiency of new antibody development and provide optimal antibody production and testing services.

Services

Antibodies are a crucial component of the immune system's arsenal in combating viral infections, and their ability to target a wide range of proteins makes antibody therapies highly valued in the biotech industry. However, the current approach to antibody design in pharmaceuticals relies heavily on laborious molecular screening processes to identify antibodies with specific properties, which is time-consuming and unable to keep pace with virus mutations.

Nowadays, Creative Biolabs has developed a high-throughput antibody production system integrated with an AI-designed antibody sequence library. The whole process is pipeline-operated, the computer monitoring program can reduce the occurrence of wrong operations, and the introduction of automation equipment can meet the needs of large-scale AI-designed or optimized derived antibody sequences.

To date, our high-throughput antibody preparation platform has completed the production of thousands of antibodies, covering a variety of molecular types such as nano-antibodies, human or humanized IgG antibodies, cytokines, and other types of recombinant antibodies, and accumulated rich experience in antibody production.

• Free codon optimization
• Short delivery cycle: the fastest 2-week delivery
• Flexible delivery volume: μg-g level
• Optimized medium and expression system
• Optimized and efficient expression vector
• High expression throughput: >1000 antibodies/week

Features

In Creative Biolabs, we offer a comprehensive range of AI-based high-throughput antibody development services. Our services focus on a series of AI-designed, engineered, and analyzed source antibodies, including but not limited to, de novo design, characterization, optimization, physicochemical properties analysis, allergenicity prediction, immunogenicity prediction, toxicity prediction, and developability evaluation.

Fig.1 High-Throughput Antibody Production Services for AI-based Antibodies.¹

Platform

Currently, the AI model has been trained on several thousand antibody sequences and has learned nearly 100 million protein sequences. A significant portion of its recommendations for antibody mutations demonstrate improved thermal stability, enhanced neutralizing activity against their target viruses, as well as improved antibody binding affinity. Moreover, our AI model is capable of not only enhancing existing antibodies but also generating new antibodies, offering alternative options for molecular targets that existing antibody design methods are unable to address.

Meanwhile, we can also conduct wet detection on generative AI antibodies. The molecules generated or optimized by the AI model are further verified and screened through high-throughput wet experiments, and the experimental data are fed back to our AI model to enhance the accuracy and confidence of AI prediction. After multiple rounds of AI design and wet experiment verification, functional molecules can be found more efficiently.

Fig.2 Artificial Intelligence-Driven Antibody Discovery.²

Advantages

Creative Biolabs is a leading CRO company in antibody discovery and optimization. Using self-collected and continuously generated high quality, high quantity, and real antibody research and development data, we have been committed to creating a new data-driven and biology-driven AI antibody development workflow, establishing a high-throughput AI antibody production platform, and producing ideal antibody drugs with infinite diversity and no boundary.

High efficiency: AI technology can quickly analyze and process large amounts of data, dramatically shortening the timeline of antibody discovery and design.

High accuracy: Deep learning models can provide highly accurate predictions and reduce trial and error in laboratory work.

High orientation: AI algorithms can take multiple properties into account when selecting candidate molecules, which can greatly reduce uncertainty in antibody engineering.

High novelty: AI can not only optimize existing antibody designs but also discover new design concepts and targets, expanding the boundaries of research.

Creative Biolabs has established a top high-throughput and integrated R&D platform for innovative antibody types and has accumulated and formed a large antibody library and other technical resources. It is suitable for challenging difficult innovative antibody targets, and it is also suitable for developing difficult new AI-sourced antibody molecules. If you are interested in our services, please feel free to contact us.

For research use only. Not intended for any clinical use.