Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
+ Filter
Loading...
Custom Services order now ship next day

KIT

Engineered Antibody Antibody Magnetic Beads
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (granulocytes, Melanocytes, Inhibitory neurons, Ionocytes, Breast glandular cells)

Immune cell specificity

Group enriched (basophil, NK-cell, eosinophil)

Cell line specificity

Group enriched (HEL, HMC-1)

Interaction

Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3 catalytic subunit. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts (KITLG/SCF-bound) with IL1RL1. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation
  • Anti-cKIT (clone 20376)-SMCC-DM1 ADC (ADC-097CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG024)-SMCC-DM1 ADC (ADC-096CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG085)-SMCC-DM1 ADC (ADC-095CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone 9P3)-SMCC-DM1 ADC (ADC-094CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone 9P3)-CX1-1-DM1 ADC (ADC-103CL)
    • Target: cKIT
    • Linker: CX1-1 (2,5-dioxopyrrolidin-1-yl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaheptadecan-1-oate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone 9P3)-SPDB-DM4 ADC (ADC-102CL)
    • Target: cKIT
    • Linker: SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
    • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG027)-SMCC-DM1 ADC (ADC-101CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG026)-SMCC-DM1 ADC (ADC-100CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG087)-SMCC-DM1 ADC (ADC-099CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-cKIT (clone NEG086)-SMCC-DM1 ADC (ADC-098CL)
    • Target: cKIT
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare