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MIB1
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (REH)
Interaction
Interacts with CEP131 and PCM1.
Molecular function
Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.