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SPHK2
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Cone photoreceptor cells, Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (NB-4)
Interaction
Interacts with histone H3 (PubMed:19729656). Interacts with HDAC1, HDAC2, MBD2 and SIN3A (PubMed:19729656). Interacts with EEF1A1; the interaction enhances SPHK2 kinase activity (PubMed:18263879). Interacts with PHB2 (By similarity).
Molecular function
Kinase, Transferase
More Types Infomation
Related Signaling Pathways
FcεR1 Signaling Pathway
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
- Mouse Anti-SPHK2 Recombinant Antibody (clone 7H5) (VS3-QX1048)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.