FcεR1 Signal pathway

About FcεR1 Pathway

The interaction between IgE receptor (FcεRI)-bound IgE and antigen induces an elaborate network of signal transduction pathways that trigger cell activation. The FcεR1 consists of an IgE-binding α chain, a β chain and a disulfide-linked γ chain homodimer. The cytoplasmic tails of β and γ subunits both contain ITAMs, which are the target of Src and Syk family protein tyrosine kinases. FcεRI is involved in the phosphorylation of Lyn and Fyn receptor ITAM, thus generating docking sites for these proteins as well as for Syk. Binding to ITAM results in up-regulation of Fyn, Lyn and Syk kinase activity and phosphorylation of downstream signal molecules. The consequence of these events is the formation of multi-protein complexes containing various signal molecules, which induce the activation of MAPK pathway and the generation of second messenger molecules, thus inducing cell activation. The FcεRI signaling pathway leads to degranulation of mast cells or basophils and release of inflammatory mediators through crosslinking of IgE-antigen complexes.

Related Pathways

PI3K-Akt Pathway

References
1. Rohit Saluja, Ingrid Delin, Gunnar P. Nilsson, Mikael Adner (2012) FcεR1-Mediated Mast Cell Reactivity Is Amplified through Prolonged Toll-Like Receptor-Ligand Treatment. PLoS One. 7(8): e43547.
2. Huihong Qiao, Marcus V. Andrade, Felipe A. Lisboa, Katrina Morgan, Michael A. Beaven (2006) FcεR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cells. Blood. 107(2): 610–618.
3. Janet M Oliver, Christopher Kepley, Enrique Ortega, Bridget S Wilsona (2000) Immunologically mediated signaling in basophils and mast cells: finding therapeutic targets for allergic diseases in the human FcεR1 signaling pathway. Immunopharmacology Volume 48, Issue 3, Pages 269-281.
4. Helen Turner, Jean-Pierre Kinet (1999) Signalling through the high-affinity IgE receptor FcεRI. Nature. 402, pages24–30.
5. Alsaleh N B, Persaud I, Brown J M (2016) Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor. Plos one. 11(12): e0167366.

For research use only. Not intended for any clinical use.