About FcεR1 Pathway

The interaction between IgE receptor (FcεRI)-bound IgE and antigen induces an elaborate network of signal transduction pathways that trigger cell activation. The FcεR1 consists of an IgE-binding α chain, a β chain and a disulfide-linked γ chain homodimer. The cytoplasmic tails of β and γ subunits both contain ITAMs, which are the target of Src and Syk family protein tyrosine kinases. FcεRI is involved in the phosphorylation of Lyn and Fyn receptor ITAM, thus generating docking sites for these proteins as well as for Syk. Binding to ITAM results in up-regulation of Fyn, Lyn and Syk kinase activity and phosphorylation of downstream signal molecules. The consequence of these events is the formation of multi-protein complexes containing various signal molecules, which induce the activation of MAPK pathway and the generation of second messenger molecules, thus inducing cell activation. The FcεRI signaling pathway leads to degranulation of mast cells or basophils and release of inflammatory mediators through crosslinking of IgE-antigen complexes.

Related Pathways

For research use only. Not intended for any clinical use.