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STAT4

Engineered Antibody
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Early spermatids, dendritic cells, T-cells, NK-cells, Excitatory neurons, Plasma cells, Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (Karpas-707, U-266/70, U-266/84)

Interaction

Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

Molecular function

Activator, DNA-binding

More Types Infomation
Related Diseases
Endometrial Cancer Endometrial Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Throid Cancer Throid Cancer
Related Signaling Pathways
MAPK Signaling Pathway MAPK Signaling Pathway

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