Human monoclonal antibody against the third variable domain (V3) of the HIV-1 gp120 envelope protein derived from HIV-1 infected individuals display the ability to neutralize primary isolates representing different clades. The human anti-V3 monoclonal Abs (mAbs) were generated from unrelated individuals infected with various subtypes of HIV-1, which preferentially used pairing of the VH5-51 and VL lambda genes. The VH5-51 anti-V3 mAbs recognized an epitope with an identical 3D structure which is mimicked by a single mimotope recognized by the majority of VH5-51-derived mAbs but not by other V3 mAbs. These data suggest that the identification of preferentially used Ig genes by neutralizing mAbs may define conserved epitopes in the diverse virus envelopes. This will be useful information for designing vaccine immunogen inducing cross-neutralizing Abs.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); Fab Fragment | Neut | Human Fab |
PFBZ-210 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L1); Fab Fragment | Neut | Human Fab |
MRO-3472CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 7F11); scFv Fragment | ELISA, FC | Human scFv |
MRO-3473CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3G8); scFv Fragment | ELISA, FC | Human scFv |
MRO-3642CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 101-451); scFv Fragment | ELISA, WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-164 | Human Anti-HIV-1 gp120 Recombinant Antibody; scFv Fragment (PSBZ-164) | Neut | Human scFv |
PSBZ-165 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01); scFv Fragment | Neut | Human scFv |
PSBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); scFv Fragment | Neut | Human scFv |
PSBZ-210 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L1); scFv Fragment | Neut | Human scFv |
PSBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment | FC, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-132LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT123) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-133LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT267) | ELISA, WB, Neut | Mouse antibody |
MRO-134LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT085) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-150LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-4) | ELISA, Inhib, FC, Neut, RIPA, DB, IP | Mouse antibody |
MRO-152LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-136) | Neut, ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3371CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone m14) | ELISA, Neut | Human IgG |
MRO-3373CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CC6C11) | ELISA, FuncS | Human IgG1, κ |
MRO-3374CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CC6B5) | ELISA, FuncS | Human IgG1, κ |
MRO-3375CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone ED47) | Inhib | Human IgG |
MRO-3376CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone ED49) | WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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