Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3674) (CAT#: MRO-4070CQ)
Recombinant human antibody to gp41. 3674 neutralized 6 out of 7 HIV strains, and only 3/10 maturated Fabs showed improved neutralization activity relative to 3674.
Specific Inquiry
WB
Figure 1 Characterization of bivalent (bF) and monovalent (mF) Fab 3674 antibodies.
Ribbon diagrams of the engineered gp41- derived constructs used in this study.
Gustchina, E., Louis, J. M., Lam, S. N., Bewley, C. A., & Clore, G. M. (2007). A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains. Journal of virology, 81(23), 12946-12953.
Neut
Figure 2 Synergistic and synchronized antiviral activities of Fab bF3674 and C34 further define the Fab 3674 epitope.
Dose response curves for antiviral activity against HXB2 Env-pseudotyped virus of
C34 (green), bF-3674 Fab (blue), and a typical fixed combination ratio
(1:10) of C34/bF-3674 (red).
Gustchina, E., Louis, J. M., Lam, S. N., Bewley, C. A., & Clore, G. M. (2007). A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains. Journal of virology, 81(23), 12946-12953.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Recognizes HIV-1 gp41
- Species Reactivity
- HIV-1
- Clone
- 3674
- Applications
- WB, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Western Blot, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 3674"
See other products for "HIV-1 gp41"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-486-S(P) | Recombinant Anti-HIV-1 gp41 Antibody scFv Fragment | FC, WB, FuncS | scFv |
| PSBC-331 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-331) | Neut | Mouse scFv |
| PSBC-332 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8v4-5R+100cF); scFv Fragment | Neut | Human scFv |
| PSBC-334 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-334) | ELISA, Neut | Mouse scFv |
| PSBC-335 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-335) | ELISA, Neut | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5); Fab Fragment | WB, Neut, FuncS | Human Fab |
| MRO-4138CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8-10fH/4fL); Fab Fragment | Neut | Human Fab |
| MRO-4139CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8-19fH/10fL); Fab Fragment | Neut | Human Fab |
| MRO-4140CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8-2fH/10fL); Fab Fragment | Neut | Human Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-025LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG3) | ELISA | Human antibody |
| MRO-026LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG1) | ELISA | Human antibody |
| MRO-040LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (M66.6) | ELISA | Human antibody |
| MRO-074LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (W) | ELISA | Human antibody |
| MRO-077LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (3D6) | ELISA | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-842CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1911) | WB | Mouse IgG2a |
| MRO-843CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 191) | WB | Mouse IgG2 |
| MRO-844CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10E9) | WB, RIPA, ELISA, IF | Mouse IgG1 |
| MRO-845CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10F6) | ELISA, WB, IP, IF | Mouse IgG2b |
| MRO-846CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1116591) | ELISA | Mouse IgG2a |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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