HIV-1 gp41
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Loading...- A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer (MHC-LC746)
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- Class: Class I
- Antigen: HIV-1 gp41
- Antigen Species: HIV-1
- Peptide: RYLKDQQLL
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- Recombinant Human Anti-HIV-1 gp41 Soluble TCR (scTCR-137CQ-S(P))
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- Species Reactivity: HIV-1
- Epitope: ERYLKDQQL
- MHC: HLA-B14
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- Recombinant Anti-HIV-1 gp41 Antibody (MOB-486)
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- Derivation: Mouse
- Species Reactivity: HIV
- Type: IgG
- Application: WB, Dot, FuncS
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- Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG3) (MRO-025LC)
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody (W) (MRO-074LC)
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- Derivation: Yeast diplay library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) (MRO-026LC)
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody (clone 43) (MRO-093LC)
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody (M66.6) (MRO-040LC)
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (W) (MRO-074LC-S(P))
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- Derivation: Yeast diplay library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG3) (MRO-025LC-S(P))
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (clone 43) (MRO-093LC-S(P))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG1) (MRO-026LC-S(P))
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (M66.6) (MRO-040LC-S(P))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG3) (MRO-025LC-F(E))
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG1) (MRO-026LC-F(E))
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- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (M66.6) (MRO-040LC-F(E))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (clone 43) (MRO-093LC-F(E))
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- Derivation: Phage display library
- Type: Human antibody
- Application: ELISA
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- Recombinant Human Anti-HIV-1 gp41 Antibody Fab Fragment (MHH-486-F(E))
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- Derivation: Human
- Species Reactivity: HIV
- Type: Fab
- Application: ELISA, IP, FuncS
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- Recombinant Human Anti-HIV-1 gp41 Antibody scFv Fragment (MHH-486-S(P))
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- Derivation: Human
- Species Reactivity: HIV
- Type: scFv
- Application: IF, Neut, FuncS
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- Recombinant Anti-HIV-1 gp41 Antibody Fab Fragment (MOB-486-F(E))
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- Derivation: Mouse
- Species Reactivity: HIV
- Type: Fab
- Application: ELISA, FacS, FuncS
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- Recombinant Anti-HIV-1 gp41 Antibody scFv Fragment (MOB-486-S(P))
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- Derivation: Mouse
- Species Reactivity: HIV
- Type: scFv
- Application: FC, WB, FuncS
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For Research Use Only. Not For Clinical Use.
Background
Env is a viral protein that serves to form the viral envelope.The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane.
gp41 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.