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HK1
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific. [provided by RefSeq, Apr 2016]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Late spermatids, Early spermatids, Horizontal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer (PubMed:10686099). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with VDAC1 (PubMed:22304920). The HK1-VDAC1 complex interacts with ATF2 (PubMed:22304920). Interacts (via N-terminal spermatogenic cell-specific region) with PFKM (via C-terminus) (By similarity).
Molecular function
Allosteric enzyme, Kinase, Transferase
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
- Mouse Anti-HK1 Recombinant Antibody (clone 18G4) (MOB-3500z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, ICC, IF
- Rabbit Anti-HK1 Recombinant Antibody (clone CBACN-268) (MRO-0734-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Human Anti-HK1 Recombinant Antibody (HPAB-0060-LSX) (HPAB-0060-LSX)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FuncS
- Human Anti-HK1 Recombinant Antibody (HPAB-0059-LSX) (HPAB-0059-LSX)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FuncS
- Human Anti-HK1 Recombinant Antibody (HPAB-0058-LSX) (HPAB-0058-LSX)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, Inhib, FuncS
- Mouse Anti-HK1 Recombinant Antibody (clone 3A10) (VS3-XY807)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P, IP, FC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
- Mouse Anti-HK1 Recombinant Antibody (VS4-WK219) (VS4-WK219)
-
- Derivation: Mouse
- Species Reactivity: Human, Dog, Pig, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, WB, ICC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
- Human Anti-HK1 Recombinant Antibody; Fab Fragment (HPAB-0060-LSX-F(E)) (HPAB-0060-LSX-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
- Human Anti-HK1 Recombinant Antibody; Fab Fragment (HPAB-0059-LSX-F(E)) (HPAB-0059-LSX-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
- Human Anti-HK1 Recombinant Antibody; Fab Fragment (HPAB-0058-LSX-F(E)) (HPAB-0058-LSX-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
- Human Anti-HK1 Recombinant Antibody; scFv Fragment (HPAB-0060-LSX-S(P)) (HPAB-0060-LSX-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Human Anti-HK1 Recombinant Antibody; scFv Fragment (HPAB-0059-LSX-S(P)) (HPAB-0059-LSX-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Human Anti-HK1 Recombinant Antibody; scFv Fragment (HPAB-0058-LSX-S(P)) (HPAB-0058-LSX-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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