Syne3

Intracellular, Membrane (different isoforms)

Cell type enhanced (Rod photoreceptor cells, Cardiomyocytes, Cone photoreceptor cells)

Low immune cell specificity

Cell line enhanced (ASC diff, ASC TERT1, Karpas-707, REH)

Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. Interacts with SUN1 and SUN2; probably forming respective LINC complexes. Interacts with PLEC (via actin-binding domain). Interacts with DST. Interacts with SYNE1 via spectrin repeats. Interacts (via KASH domain) with TOR1A (ATP-bound); the interaction is required for SYNE3 nuclear envelope localization.