Rabbit Anti-SYNE3 Recombinant Antibody (clone R05-1B8) (CAT#: VS3-FY1798)

• Immunogen
• Recombinant human Nesprin3 protein

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human SYNE3

• Species Reactivity
• Human

• Clone
• R05-1B8

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 112 kDa, while the observed molecular weight stands at 112 kDa.

• Related Disease
• Spermatogenic Failure 16 and Male Infertility Due To Acephalic Spermatozoa

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341

• Gene ID
• 161176

• UniProt ID
• Q6ZMZ3

• Sequence Similarities
• Belongs to the nesprin family.

• Cellular Localization
• Endoplasmic reticulum, Membrane, Nucleus

• Post Translation Modifications
• The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces. (Q6ZMZ3-SYNE3_HUMAN)
  Modification sites at PhosphoSitePlus (Q6ZMZ3)
  Modification sites at neXtProt (NX_Q6ZMZ3)
  Glycosylation from GlyGen (Q6ZMZ3) 2 sites, 2 O-linked glycans (2 sites)

• Protein Refseq
• NP_001350621.1; NP_001371210.1; NP_001371211.1; NP_001371212.1; NP_001371213.1

• Function
• As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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