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TREM2
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Human disease related genes
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Group enriched (hTCEpi, THP-1)
Interaction
Monomer (PubMed:27995897). After ectodomain shedding, the extracellular domain oligomerizes, which is enhanced and stabilized by binding of phosphatidylserine (PubMed:29794134). Interacts with TYROBP/DAP12 (PubMed:11602640, PubMed:25957402). Interaction with TYROBP is required for stabilization of the TREM2 C-terminal fragment (TREM2-CTF) which is produced by proteolytic processing (PubMed:25957402).
Molecular function
Receptor
More Types Infomation
- Mouse Anti-TREM2 Recombinant Antibody (HPAB-0156-CN) (HPAB-0156-CN)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA, FC, IHC, IF, IP
- Human Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0157-CN-F(E)) (HPAB-0157-CN-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0156-CN-F(E)) (HPAB-0156-CN-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0155-CN-F(E)) (HPAB-0155-CN-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0154-CN-F(E)) (HPAB-0154-CN-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA, FC, IHC, IF, IP
- Human Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0157-CN-S(P)) (HPAB-0157-CN-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0156-CN-S(P)) (HPAB-0156-CN-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0155-CN-S(P)) (HPAB-0155-CN-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0154-CN-S(P)) (HPAB-0154-CN-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody (HPAB-0155-CN) (HPAB-0155-CN)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, IHC, IF, IP
- Mouse Anti-TREM2 Recombinant Antibody (HPAB-0154-CN) (HPAB-0154-CN)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, IHC, IF, IP
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005) (HPAB-0153-CN)
-
- Species Reactivity: Human, Mouse
- Type: Human IgG1, κ
- Application: ELISA, FC
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002) (HPAB-0152-CN)
-
- Species Reactivity: Human, Mouse
- Type: Human IgG1, κ
- Application: ELISA, FC
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005); Fab Fragment (HPAB-0153-CN-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, FC
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002); Fab Fragment (HPAB-0152-CN-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, FC
-
- Species Reactivity: Human, Mouse
- Type: Human IgG
- Application: ELISA, FC, WB, FuncS
-
- Derivation: Human synthetic yeast libraries
- Species Reactivity: Human, Mouse
- Type: Human IgG
- Application: ELISA, FC, WB, FuncS
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005); scFv Fragment (HPAB-0153-CN-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, FC
- Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002); scFv Fragment (HPAB-0152-CN-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Human scFv
- Application: ELISA, FC
- Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-169CQ-F(E)) (TAB-169CQ-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Human Fab
- Application: ELISA, FC, WB, FuncS
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For Research Use Only. Not For Clinical Use.