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VAV2

Engineered Antibody
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatocytes, Inhibitory neurons)

Immune cell specificity

Immune cell enhanced (memory B-cell)

Cell line specificity

Low cell line specificity

Interaction

Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent.

Molecular function

Guanine-nucleotide releasing factor

More Types Infomation
Related Signaling Pathways
FcεR1 Signaling Pathway FcεR1 Signaling Pathway
TCR Signaling Pathway TCR Signaling Pathway

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