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Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5)

Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5) (CAT#: VS3-FY1537)

Name: Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5)
SKU: VS3-FY1537
Rating: 5 (1 reviews)

This product is a recombinant rabbit antibody that recognizes VAV2. This antibody has been reported for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation. The clone R06-8F5 is specific for human VAV2. The antigen is synthetic peptide of human vav2.

Tested Data
Gene Expression
Datasheet
MSDS
COA

ICC

Figure 1. Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5) in ICC.

Figure 1. Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5) in ICC.

Immunocytochemical analysis of VAV2 (green) in HeLa using VAV2 antibody and DAPI (blue).

Figure 2. Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5) in WB.

Figure 2. Recombinant Rabbit Anti-VAV2 Antibody (clone R06-8F5) in WB.

Western Blot analysis of VAV2 in Hela, MCF-7, HepG2, U2OS, U251 lysates using VAV2 Antibody.

Subcellular Location

Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/if_selected.jpg

Normal Tissue

Figure 2 IHC staining of human gall bladder
(Immunohistochemical staining of human gall bladder shows cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/ihc_selected.jpg

Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/9525_B_7_5.jpg

Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/9525_A_7_3.jpg

Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/9525_A_7_4.jpg

Figure 6 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/9525_A_8_5.jpg

Figure 7 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3224/9525_A_6_6.jpg

RNA Expression

Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160293-VAV2

Datasheet

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
Synthetic peptide of human VAV2.

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human VAV2

Species Reactivity
Human

Clone
R06-8F5

Applications
Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation

Conjugate
Unconjugated

MW
Calculated MW: 101 kDa; Observed MW: 101 kDa

Product Property

Purification
Affinity Purified

Purity
>95% as determined by SDS-PAGE

Buffer
50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA

Preservative
0.01% Sodium azide

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
Western Blot: 1/500-1/1000
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20

Target

Alternative Names
Vav Guanine Nucleotide Exchange Factor 2; Vav 2 Guanine Nucleotide Exchange Factor; Vav 2 Oncogene; VAV-2; Guanine Nucleotide Exchange Factor VAV2

Gene ID
7410

UniProt ID
P52735

Cellular Localization
Cytoplasm, Cytosol, Plasma membrane

Post Translation Modifications
Phosphorylated on tyrosine residues in response to FGR activation.

Protein Refseq
NP_001127870.1; NP_003362.2

Function
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Secondary Antibody

Isotype Control

Related Resources

Related Signaling Pathways

FcεR1 Signaling Pathway

TCR Signaling Pathway

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT	Product Name	Application	Type
MOB-2861z	Mouse Anti-VAV2 Recombinant Antibody (clone 23H11)	WB, ELISA, FC	Mouse IgG1
MRO-1573-CN	Rabbit Anti-VAV2 Recombinant Antibody (clone CBACN-575)	WB, IF, IHC, IP	Rabbit IgG
VS3-CJ1031	Rabbit Anti-VAV2 Recombinant Antibody (VS3-CJ1031)	WB, ICC, IHC, IP	Rabbit IgG
VS3-XY1582	Mouse Anti-VAV2 Recombinant Antibody (clone 3B11E4)	ELISA, WB, FC	Mouse IgG1
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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