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WNT2B
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Peritubular cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, HSkMC, SuSa, TIME)
Interaction
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD4 and FZD5 (By similarity).
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
mTOR Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Endometrial Cancer
Throid Cancer
Cushing Syndrome
- Rabbit Anti-WNT2B Recombinant Antibody (clone JB48-34) (MRO-1599-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IF, FC
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ICC, IF, WB, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.