Cancer-related genes, Disease related genes, Human disease related genes
Cell type enhanced (Basal keratinocytes, Alveolar cells type 2, Distal enterocytes, Suprabasal keratinocytes)
Not detected in immune cells
Cell line enhanced (CACO-2, HeLa, hTERT-HME1, RT4)
Homodimer; disulfide-linked (PubMed:10074410). Interacts with SOSTDC1 (PubMed:15020244). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631). Interacts with type I receptor BMPR1A (PubMed:15064755). Interacts with type II receptor BMPR2 (PubMed:7791754). Interacts with SCUBE3 (PubMed:33308444). Interacts with TNFAIP6 (primarily via Link domain); this interaction is inhibited by hyaluronan.
Cytokine, Developmental protein, Growth factor
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