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    Human Anti-BMP2 Recombinant Antibody (clone 11F2) (CAT#: HPAB-0170-YC)

    Provided herein are antibodies directed against bone morphogenic proteins (BMPs). The antibodies are useful for the treatment of diseases, such as bone diseases and cancers mediated by BMP expression or associated with abnormal expression of a receptor therefor.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA

    Figure 1 Densitometry scanning that bone formation is significantly reduced by the anti-BMP2 monoclonal antibodies.

    Figure 1 Densitometry scanning that bone formation is significantly reduced by the anti-BMP2 monoclonal antibodies.

    Inhib

    Figure 2 Inhibition of BMP2 and BMP4 signaling by anti-BMP2/4 antibodies.

    Figure 2 Inhibition of BMP2 and BMP4 signaling by anti-BMP2/4 antibodies.

    C2C12 cells were incubated with recombinant human BMP4 and varying concentrations of five different neutralizing anti-BMP2/4 monoclonal antibodies or IgG1 control mAb. Cells were fixed, lysed, and assayed for alkaline phosphatase activity.

    Block

    Figure 3 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-II BMP receptors by Biacore analysis.

    Figure 3 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-II BMP receptors by Biacore analysis.


    Specifications

    • Immunogen
    • Recombinant human BMP2
    • Host Species
    • Human
    • Type
    • Human IgG
    • Specificity
    • Human BMP2
    • Species Reactivity
    • Human
    • Clone
    • 11F2
    • Applications
    • ELISA, FC, IHC, WB, Block
    • Related Disease
    • Abnormal bone formation, Ossification mediated by BMP2

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been tested for use in Blocking.

    Target

    • Alternative Names
    • BDA2; BMP2A

    Related Resources

    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 11F2"

    See other products for "BMP2"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Neutralizing Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products
    CAT Product Name Application Type
    MOB-2245z Mouse Anti-BMP2 Recombinant Antibody (clone 29F12) WB, ELISA, FC, ICC, IHC Mouse IgG1
    MOB-0446CT Mouse Anti-BMP2 Recombinant Antibody (clone NN0225-8C42) IHC-P, WB Mouse IgG2
    HPAB-0169-YC Human Anti-BMP2 Recombinant Antibody (clone 8B3) ELISA, FC, IHC, WB, Block Human IgG
    VS3-XY129 Mouse Anti-BMP2 Recombinant Antibody (clone 4H8H8E2) ELISA, WB, ICC, FC Mouse IgG1
    VS3-FY161 Recombinant Rabbit Anti-BMP2 Antibody (clone R03-3H9) WB, ICC, IF Rabbit IgG

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