Provided herein are antibodies directed against bone morphogenic proteins (BMPs). The antibodies are useful for the treatment of diseases, such as bone diseases and cancers mediated by BMP expression or associated with abnormal expression of a receptor therefor.
Figure 1 Densitometry scanning that bone formation is significantly reduced by the anti-BMP2 monoclonal antibodies.
Figure 2 Inhibition of BMP2 and BMP4 signaling by anti-BMP2/4 antibodies.
C2C12 cells were incubated with recombinant human BMP4 and varying concentrations of five different neutralizing anti-BMP2/4 monoclonal antibodies or IgG1 control mAb. Cells were fixed, lysed, and assayed for alkaline phosphatase activity.
Figure 3 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-II BMP receptors by Biacore analysis.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
|MOB-2245z||Mouse Anti-BMP2 Recombinant Antibody (clone 29F12)||WB, ELISA, FC, ICC, IHC||Mouse IgG1|
|MOB-0446CT||Mouse Anti-BMP2 Recombinant Antibody (clone NN0225-8C42)||IHC-P, WB||Mouse IgG2|
|HPAB-0169-YC||Human Anti-BMP2 Recombinant Antibody (clone 8B3)||ELISA, FC, IHC, WB, Block||Human IgG|
|MRO-1697-CN||Rabbit Anti-BMP2 Polyclonal Antibody (MRO-1697-CN)||WB, IF, IHC, FC||Rabbit IgG|
|VS3-XY129||Mouse Anti-BMP2 Recombinant Antibody (clone 4H8H8E2)||ELISA, WB, ICC, FC||Mouse IgG1|
|NEUT-050CQ||Mouse Anti-BMP2 Recombinant Antibody (clone CBL720)||Neut, WB||Mouse IgG1|
|MOR-3977||Hi-Affi™ Rabbit Anti-BMP2 Recombinant Antibody (clone SI37DS)||IF||Rabbit IgG|
|HPAB-0169-YC-S(P)||Human Anti-BMP2 Recombinant Antibody (clone 8B3); scFv Fragment||ELISA, FC, IHC, WB||Human scFv|
|HPAB-0170-YC-S(P)||Human Anti-BMP2 Recombinant Antibody (clone 11F2); scFv Fragment||ELISA, FC, IHC, WB||Human scFv|
|HPAB-0169-YC-F(E)||Human Anti-BMP2 Recombinant Antibody (clone 8B3); Fab Fragment||ELISA, FC, IHC, WB||Human Fab|
|HPAB-0170-YC-F(E)||Human Anti-BMP2 Recombinant Antibody (clone 11F2); Fab Fragment||ELISA, FC, IHC, WB||Human Fab|
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.