Human Anti-BMP2 Recombinant Antibody (clone 8B3)
CAT#: HPAB-0169-YC
Provided herein are antibodies directed against bone morphogenic proteins (BMPs). The antibodies are useful for the treatment of diseases, such as bone diseases and cancers mediated by BMP expression or associated with abnormal expression of a receptor therefor.
Published Data
Gene Expression
Block
Figure 1 Anti-BMP2/4 monoclonal antibodies blocking BMP4 binding to type-II BMP receptors by Biacore analysis.
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Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/58610/1596_D8_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78457/1727_A2_1_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, HeLa, hTERT-HME1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125845-BMP2
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Specifications
- Immunogen
- Recombinant human BMP2
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human BMP2
- Species Reactivity
- Human
- Clone
- 8B3
- Applications
- ELISA, FC, IHC, WB, Block
- Related Disease
- Abnormal bone formation, Ossification mediated by BMP2
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Blocking.
Target
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High Specificity and Affinity
This antibody was proven to be effective in our western blot assays. The target protein presents a single, clear band, and within an appropriate exposure time, the signal of the target strip was strong enough that enabled us to observe and quantify.
Reliable and Consistent Results
The consistent results were obtained after the repeated experiments in our ELISA and flow cytometry assays. The human anti-BMP2 recombinant antibody (clone 8B3) is a highly reproducible antibody, ensuring the reliability of our experimental results.
Q&As
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Is it possible to use this antibody for IHC (mouse mesenchymal stem cells)?
A: This antibody has not yet been tested in mouse, so that it is not a recommended species at this time. So it may not necessarily obtain ideal results in mouse mesenchymal stem cells.
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Can the human anti-BMP2 recombinant antibody (clone 8B3) be used to stain paraffin embedded tissue?
A: Yes, the human anti-BMP2 recombinant antibody (clone 8B3) be used to stain paraffin embedded tissue. We have tested its effectiveness in the IHC.
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How many microliters is the minimum size?
A: The minimum specification of the human anti-BMP2 recombinant antibody (clone 8B3) is supplied as 500 µg and the purity is greater than 95% as determined by SDS-PAGE and HPLC analysis.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Signaling Pathways
TGF-β Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone 8B3"
- CAT
- Product Name
See other products for "BMP2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2245z | Mouse Anti-BMP2 Recombinant Antibody (clone 29F12) | WB, ELISA, FC, ICC, IHC | Mouse IgG1 |
| MRO-1697-CN | Rabbit Anti-BMP2 Polyclonal Antibody (MRO-1697-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY161 | Recombinant Rabbit Anti-BMP2 Antibody (clone R03-3H9) | WB, ICC, IF | Rabbit IgG |
| VS7-HM240 | Mouse Anti-BMP2 Recombinant Antibody (clone 9E10D6) | FCM | Mouse IgG1 |
| VS7-HM241 | Mouse Anti-BMP2 Recombinant Antibody (clone 9E10G12) | ICC, FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-050CQ | Mouse Anti-BMP2 Recombinant Antibody (clone CBL720) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3977 | Hi-Affi™ Rabbit Anti-BMP2 Recombinant Antibody (clone SI37DS) | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0169-YC-S(P) | Human Anti-BMP2 Recombinant Antibody (clone 8B3); scFv Fragment | ELISA, FC, IHC, WB | Human scFv |
| HPAB-0170-YC-S(P) | Human Anti-BMP2 Recombinant Antibody (clone 11F2); scFv Fragment | ELISA, FC, IHC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0169-YC-F(E) | Human Anti-BMP2 Recombinant Antibody (clone 8B3); Fab Fragment | ELISA, FC, IHC, WB | Human Fab |
| HPAB-0170-YC-F(E) | Human Anti-BMP2 Recombinant Antibody (clone 11F2); Fab Fragment | ELISA, FC, IHC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY797 | Anti-BMP2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC23 | Recombinant Anti-BMP2 (AA 282-299 x AA 369-383) Biparatopic Antibody, Tandem scFv (Clone 11F2 x Clone 8B3) | Block, ELISA, FC, IHC, WB | Tandem scFv |
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