Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
  • Home
  • Gene
  • EGFR & IGF-1R
+ Filter
Loading...
Custom Services order now ship next day

EGFR & IGF-1R

Engineered Antibody Antibody-like Scaffold Protein Glyco-Abs MHC Antibody Magnetic Beads
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
EGFR & IGF-1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: MTX
    Go to compare Compare
  • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
    • Target: EGFR
    • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
    • Drug: doxorubicin
    Go to compare Compare
  • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
    • Target: EGFR
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: doxorubicin
    Go to compare Compare
  • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
    • Target: EGFR variant III
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
    Go to compare Compare
  • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
    • Target: EGFRvIII
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
    Go to compare Compare
  • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
    Go to compare Compare
  • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
    • Target: EGFR
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
    Go to compare Compare
  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
    Go to compare Compare
  • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
    • Target: epidermal growth factor receptor (EGFR)
    • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MODO (monomethyldolastatin)
    Go to compare Compare
  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
    Go to compare Compare
More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

  • 0
  • 0
Cart
    Inquiry
    Go to compare

    Go to compare