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NCOA4
Loading...Anti-NCOA4 Products
- Anti-NCOA4 Immunohistochemistry Kit (VS-0525-XY4715)
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- Species Reactivity: Human
- Target: NCOA4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Macrophages)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.
Molecular function
Activator
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