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    Proteolytic Enzyme Products

    Creative Biolabs has rich experience in antibody and protein-related research. With decades of team dedication, we not only provide you with high-quality antibody products and services but also offer you characterization tools for researching antibodies. Creative Biolabs provides powerful characterization analysis proteolytic enzymes for monoclonal antibodies, fusion protein products, etc., empowering every customer in antibody and protein research.

    Introduction

    Proteases are a type of highly specific, multifunctional enzymes with protein hydrolyzing activities that play important roles in life and disease. Proteases cut proteins by cleaving peptide bonds between amino acids at specific sites. By degrading proteins, proteases participate in regulating various biological processes, including cell proliferation, differentiation, signal transduction, and immune response. In terms of diseases, proteases also play vital roles, making them a focus of the pharmaceutical industry. In the research and development process of biopharmaceuticals, proteases can assist in comprehensive and in-depth characterization analysis of monoclonal antibodies and other biological molecular drugs.

    As powerful tools in protein research, proteases play a significant role, especially in the preparation of samples for mass spectrometry analysis (MS), which helps us understand the structure, function, and interactions of proteins.

    Proteolytic Enzymes

    Creative Biolabs offers a variety of protease products for you. Some are suitable for obtaining antibody fragments, some are suitable for digesting fusion protein linkers, and some are suitable for research on protein post-translational modifications.

    Proteases that hydrolyze antibodies yielding antibody fragments can cleave IgG/A/M in multiple species and subtypes. The related products are listed below:

    Enzyme Name Cat
    IgG-digesting Enzyme A (Yielding F(ab')2 and Fc) VS-0724-CJ1
    IgG-digesting Enzyme B (Yielding F(ab')2 and Fc) VS-0724-CJ2
    Human IgG1-digesting Enzyme A (Yielding Fab and Fc) VS-0724-CJ3
    Human IgG1-digesting Enzyme B (Yielding Fab and Fc) VS-0724-CJ4
    Human IgG1-digesting Enzyme C (Yielding Fab and Fc) VS-0724-CJ5
    IgG-digesting Enzyme (Yielding Fab and Fc) VS-0724-CJ6
    Human IgA1-digesting Enzyme (Yielding Fab and Fc) VS-0724-CJ7
    Human IgA1/A2m1-digesting Enzyme (Yielding Fab and Fc) VS-0724-CJ8
    Human IgM-digesting Enzyme (Yielding F(ab')2 and Fc) VS-0724-CJ9

    We can provide a variety of deglycosylation enzymes for cleaving various types of glycans to facilitate deglycosylation of antibodies, fusion proteins, or peptides. The related products are listed below:

    Enzyme Name Cat
    Deglycosylation Enzyme A (Hydrolyzes Mucin-type O-glycans) VS-0724-CJ16
    Deglycosylation Enzyme B (Hydrolyzes Core 1 Mucin-type O-glycans) VS-0724-CJ17
    Deglycosylation Enzyme C (Hydrolyzes Core 1 O-glycans) VS-0724-CJ18
    Deglycosylation Enzyme D (Hydrolyzes Sialic Acids) VS-0724-CJ19
    Deglycosylation Enzyme E (Hydrolyzes Fucose) VS-0724-CJ20
    Deglycosylation Enzyme F (Hydrolyzes N-glycans) VS-0724-CJ15
    Deglycosylation Enzyme G (Hydrolyzes β-galactose) VS-0724-CJ21
    Deglycosylation Enzyme N (Hydrolyzes GalNAc) VS-0724-CJ22

    In addition to the products listed above, we welcome you to explore more of our enzyme products. Creative Biolabs is ready to provide you with the best assistance in biopharmaceutical research and development or routine quality control. If you have any other questions or needs, please feel free to contact us.

    • Endoglycosidase H (VS-0724-CJ26)
      • Cleavage Site: High mannose or hybrid N-glycans
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 1-hour reaction
      • Format: Liquid or lyophilized
      • Original Source: S. plicatus
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    • Endoglycosidase S2 (VS-0724-CJ25)
      • Cleavage Site: IgG Fc N-glycans, β1,4-linkage between the two innermost GlcNAc residues
      • Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit, Sheep, Goat, Cow, Horse
      • Specificity: Human IgG1-4; Mouse, Rat, Monkey, Rabbit, Sheep, Goat, Cow, Horse IgG
      • Reaction Condition: 30-minute reaction; Native IgG fold
      • Format: Lyophilized; Immobilized; Kit
      • Original Source: S. pyogenes
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    • Endoglycosidase S (VS-0724-CJ24)
      • Cleavage Site: IgG Fc N-glycans, β1,4-linkage between the two innermost GlcNAc residues
      • Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit, Sheep, Goat, Cow, Horse
      • Specificity: Human IgG1-4; Mouse, Rat, Monkey, Rabbit, Sheep, Goat, Cow, Horse IgG
      • Reaction Condition: 30-minute reaction; Native IgG fold
      • Format: Lyophilized; Immobilized
      • Original Source: S. pyogenes
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    • O-glycopeptides Binding Enzyme Kit (VS-0724-CJ23)
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 30-min to 2-hour reaction; After desialylation
      • Format: Kit
      • Original Source: A. muciniphila; Engineered
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    • Deglycosylation Enzyme N (Hydrolyzes GalNAc) (VS-0724-CJ22)
      • Cleavage Site: α-linked GalNAc residues
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2 to 18-hour reaction; No need for co-factors
      • Format: Lyophilized; Immobilized
      • Original Source: A. muciniphila
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    • Deglycosylation Enzyme G (Hydrolyzes β-galactose) (VS-0724-CJ21)
      • Cleavage Site: β-galactose
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2-hour reaction; No need for co-factors
      • Format: Lyophilized; Immobilized
      • Original Source: A. muciniphila
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    • Deglycosylation Enzyme E (Hydrolyzes Fucose) (VS-0724-CJ20)
      • Cleavage Site: ɑ1-2,3,4-linked fucose
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 1 to 2-hour reaction; No need for co-factors
      • Format: Lyophilized; Immobilized
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    • Deglycosylation Enzyme D (Hydrolyzes Sialic Acids) (VS-0724-CJ19)
      • Cleavage Site: α2-3, α2-6 and α2-8-linked sialic acids
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2-hour reaction; No need for co-factors
      • Format: Lyophilized; Immobilized
      • Original Source: A. muciniphila
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    • Deglycosylation Enzyme C (Hydrolyzes Core 1 O-glycans) (VS-0724-CJ18)
      • Cleavage Site: O-glycans
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2 to 4-hour reaction; Requires removal of terminal sialic acids
      • Format: Lyophilized
      • Original Source: S. oralis
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    • Deglycosylation Enzyme B (Hydrolyzes Core 1 Mucin-Type O-glycans) (VS-0724-CJ17)
      • Cleavage Site: N-terminally of core 1 O-glycosylated serine (Ser, S) and threonine (Thr,T) residues
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2-hour to overnight reaction
      • Format: Lyophilized
      • Original Source: A. muciniphila
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    • Deglycosylation Enzyme A (Hydrolyzes Mucin-Type O-glycans) (VS-0724-CJ16)
      • Cleavage Site: N-terminally of O-glycosylated serine (Ser, S) and threonine (Thr,T)
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 2-hour reaction; No need for co-factors
      • Format: Lyophilized
      • Original Source: P. aeruginosa
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    • Deglycosylation Enzyme F (Hydrolyzes N-glycans) (VS-0724-CJ15)
      • Cleavage Site: N-linked glycans on glycoproteins
      • Species Reactivity: No species dependent
      • Specificity: Glycoproteins
      • Reaction Condition: 1 to 18-hour reaction (native condition); 15 to 60-minute reaction (denaturing condition)
      • Format: Lyophilized; Immobilized
      • Original Source: E. meningoseptica
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    • Arg Residues-digesting Enzyme (C-terminal) (VS-0724-CJ13)
      • Cleavage Site: C-terminal Arg residues (including Arg-Pro motifs)
      • Species Reactivity: No species dependent
      • Specificity: Any peptide with C-terminal arginine residues
      • Reaction Condition: 1-hour reaction; Reducing conditions
      • Format: Lyophilized
      • Original Source: P. aeruginosa
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    • IgG-conjugating Enzyme Kit (Fc N-glycan sites) (VS-0724-CJ11)
      • Cleavage Site: Fc N-glycan
      • Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit, Sheep, Goat, Cow, Horse
      • Specificity: IgG of human, mouse, rat, monkey, rabbit, sheep, goat, cow, horse
      • Reaction Condition: 2 to 3-day reaction
      • Format: Kit
      • Original Source: S. pyogenes; Engineered
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    • G/GS Linker-digesting Enzyme (VS-0724-CJ10)
      • Cleavage Site: Mutiple sites in G or GS-rich linkers
      • Species Reactivity: No species dependent
      • Specificity: G or GS-rich linkers
      • Reaction Condition: 1-hour reaction
      • Format: Lyophilized; Immobilized
      • Original Source: Phage K
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    • Human IgA1/A2m1-digesting Enzyme (Yielding Fab and Fc) (VS-0724-CJ8)
      • Cleavage Site: Above the hinge: PCP | VPS (IgA1); PCP | VPP (IgA2m1)
      • Species Reactivity: Human
      • Specificity: Human IgA1, IgA2m1
      • Reaction Condition: Overnight reaction; Physiological buffers
      • Format: Lyophilized
      • Original Source: Erysipelatoclostridium ramosum
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    • Human IgA1-digesting Enzyme (Yielding Fab and Fc) (VS-0724-CJ7)
      • Cleavage Site: Above the hinge: TPP | TPS
      • Species Reactivity: Human
      • Specificity: Human IgA1
      • Reaction Condition: 1-hour reaction; Physiological buffers
      • Format: Lyophilized
      • Original Source: S. oralis
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    • IgG-digesting Enzyme (Yielding Fab and Fc) (VS-0724-CJ6)
      • Cleavage Site: Above the hinge: THT | CPP (Human IgG1)
      • Species Reactivity: Human, Mouse, Rat, Monkey, Goat, Sheep, Rabbit
      • Specificity: IgG of human, mouse, rat, monkey, goat, sheep, rabbit
      • Reaction Condition: 1-hour reaction; Reducing conditions
      • Format: Lyophilized; Kit
      • Original Source: S. pyogenes
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    • Human IgG1-digesting Enzyme C (Yielding Fab and Fc) (VS-0724-CJ5)
      • Cleavage Site: Above the hinge: CDK | THT
      • Species Reactivity: Human
      • Specificity: Human IgG1
      • Reaction Condition: 2-hour reaction; Physiological buffers (without phosphate)
      • Format: Lyophilized
      • Original Source: B. Bacteriovorus
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    • Human IgG1-digesting Enzyme B (Yielding Fab and Fc) (VS-0724-CJ4)
      • Cleavage Site: Above the hinge: CDK | THT
      • Species Reactivity: Human
      • Specificity: Human IgG1
      • Reaction Condition: 1-hour reaction; Reducing agent (cysteine)
      • Format: Lyophilized; Kit
      • Original Source: P. gingivalis
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    • Human IgG1-digesting Enzyme A (Yielding Fab and Fc) (VS-0724-CJ3)
      • Cleavage Site: Above the hinge: DKT | HTC
      • Species Reactivity: Human
      • Specificity: Human IgG1
      • Reaction Condition: Overnight reaction; Physiological buffers
      • Format: Lyophilized; Immobilized; Kit
      • Original Source: S. agalactiae
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    • IgG-digesting Enzyme B (Yielding F(ab')₂ and Fc) (VS-0724-CJ2)
      • Cleavage Site: Below the hinge: LLG | GPS (Human IgG1; Mouse IgG2a); ILG | GPS (Mouse IgG3)
      • Species Reactivity: Human, Mouse, Monkey, Rabbit, Sheep
      • Specificity: Human IgG1-4; Mouse IgG2a and IgG3; Some Classes of monkey, rabbit and sheep
      • Reaction Condition: 2-hour reaction; Physiological buffers
      • Format: Lyophilized; Immobilized; Kit
      • Original Source: S. equi ssp. Zooepidemicus
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    • IgG-digesting Enzyme A (Yielding F(ab')₂ and Fc) (VS-0724-CJ1)
      • Cleavage Site: Below the hinge: LLG | GPS (Human IgG1)
      • Species Reactivity: Human, Mouse, Rat, Monkey, Rabbit, Sheep
      • Specificity: Human IgG1-4; Some classes of rat, monkey, rabbit and sheep
      • Reaction Condition: 30-minute reaction; Physiological buffers
      • Format: Lyophilized; Immobilized; Kit
      • Original Source: S. pyogenes
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