Radioisotope Labeled Antibody Production Services

Creative Biolabs welcomes customers to inquire about our radioisotope-labeled antibody-related services. Our radioisotope labeling process ensures maximum sensitivity and specificity, giving you confidence in your data. If you are looking for custom labeling services or need assistance with data analysis, we are here to help.

Platform

The antibody, when conjugated with radioactive substances, can target and destroy tumor cells despite variability in tumor antigen expression. This makes it a promising method for tumor therapy. As a result, Creative Biolabs has generated a novel platform that can be used for producing various radioisotopically labeled antibodies. Our team of experts has years of experience in the field of radioisotope labeling and antibody production, ensuring that you receive the highest quality products for your research needs. Whether you need antibodies labeled with different radioisotopes such as ¹²⁵I, ¹³¹I, or ³²P, we have the knowledge and technology to meet your requirements.

Fig.1 Radiohalogenation Methods for Labeled Antibody Production.^1,3

Services

When you choose our company for your radioisotopically labeled antibodies needs, you can be confident that you are receiving the best service available. Our service process starts with a comprehensive consultation to understand your project requirements and goals. We then work closely with you to develop a customized plan that ensures the successful labeling of your antibodies with radioisotopes. Our team has extensive experience in radioisotope labeling techniques and can guarantee precise and accurate results every time.

1. Selection of the antibody: A specific monoclonal or polyclonal antibody is selected based on its specificity for the target antigen.
2. Purification of the antibody: The selected antibody is purified using techniques such as protein A or protein G affinity chromatography to remove any contaminants.
3. Conjugation of the antibody: The purified antibody is conjugated with a radioisotope such as iodine-125, iodine-131, or technetium-99m. The radioisotope is typically attached to the antibody using a linker molecule that ensures stable binding.
4. Quality control: The radioisotope-labeled antibody is subjected to strict quality control measures to ensure purity, stability, and specific activity.
5. Sterile filtration: The labeled antibody is sterile-filtered to remove any potential contaminants before use in in vivo studies.
6. Storage: The radioisotope-labeled antibody is stored under appropriate conditions to maintain stability and activity.

Fig.2 PET/CT Imaging by Using ⁸⁹Zr Labeled Full Antibodies.^2,3

Case Study

Creative Biolabs has many equipment and facilities that allow us to provide accurate and reliable radioisotope labeling of antibodies. Our customer service team is always available to answer any questions you may have and provide support throughout the process.

Iodine labeling using chloramine-T is a widely utilized method for antibody and radioisotope labeling in our labs. This technique is favored for its simplicity, speed, ease of use, reproducibility, and ability to produce high-purity, high-specific-activity labeled products. Usually, our team starts by dissolving chloramine-T in water, then adding sodium bisulfite as a reducing agent to halt oxidation, and finally separating the iodine-labeled antibody protein from any free iodine through dialysis or gel chromatography filtration.

• Abundant source and low price;
• Compared with the protein labeling method, it is stable and feasible;
• Normal tissue retention time is short;
• It can also be used for diagnosis and treatment.

Creative Biolabs is committed to delivering outstanding radioisotope-labeled antibody products that meet your unique needs and exceed your expectations. Don't settle for anything less than the best choice for our company for all your radioisotope labeling needs. Contact us to learn more about our services and how we can help you achieve your research goals.

References

1. Suzuki, Hiroyuki, Kento Kannaka, and Tomoya Uehara. "Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies." Pharmaceuticals 17.4 (2024): 508.
2. Lai, Jianhao, et al. "PET imaging of Aspergillus infection using Zirconium-89 labeled anti-β-glucan antibody fragments." European Journal of Nuclear Medicine and Molecular Imaging (2024): 1-12.
3. under Open Access License CC BY 4.0, without modification.

For research use only. Not intended for any clinical use.