Functional Antibody Production and QC Services
Background
Functional antibodies are versatile tools in modern medicine and research. Engineered to perform specific tasks, such as neutralizing toxins, blocking cell signaling, or delivering therapeutic payloads, they offer numerous advantages. By precisely targeting specific molecules, functional antibodies enhance efficacy, reduce side effects, and accelerate drug discovery. Beyond therapeutics, functional antibodies are invaluable research tools, aiding in protein function studies, cellular signaling pathway investigations, and drug target identification. Therefore, it is important to develop and engineer functional antibodies with enhanced efficiency and safety.
Fig.1 Multiple effector functions mediated by antibodies.1
Functional Antibody Production & QC Service at Creative Biolabs
Creative Biolabs offers a comprehensive functional antibody production and quality control service to meet the diverse needs of the global scientific community. Our team of experts specializes in engineering and producing antibodies with a wide range of functional properties, including stable antibodies, pH-sensitive antibodies, and internalizing antibodies. Our services encompass antibody design, expression, purification, formulation, and rigorous quality control to ensure optimal performance and stability. We utilize advanced eukaryotic expression systems to guarantee correct protein folding and modification, while stringent quality control measures ensure high purity and yield. Our robust antibody production platform enables us to deliver outstanding results within the desired timelines.
- Identify the target antigen and desired functionality.
- Design the antibody sequence, including variable and constant regions.
- Optimize the sequence for expression and stability.
- Choose an appropriate eukaryotic expression system, such as CHO cells, HEK293 cells, or insect cells.
- Consider factors like post-translational modifications, protein expression levels, and scalability.
- Generate stable cell lines expressing the target antibody.
- Optimize cell culture conditions for high-yield production.
- Transfect cells with the antibody expression vector.
- Culture cells under optimal conditions to induce antibody production.
- Purify the antibody using chromatographic techniques like affinity chromatography, ion exchange chromatography, and size-exclusion chromatography.
- Remove impurities and contaminants to obtain a highly pure product.
Service Packages
High Stable Antibody Production and QC Service
- Creative Biolabs provides cost-effective, highly stable antibody production and quality control services. Based on our advanced stable eukaryotic expression system, we are committed to providing highly stable antibody products to global customers and promoting the development of major therapeutic projects.
pH-Sensitive Antibody Production and QC Service
- pH significantly impacts antibody structure, stability, and function. Creative Biolabs provides a specialized pH-sensitive antibody production and QC service. By incorporating pH-sensitive elements, we engineer antibodies with precise pH-dependent binding, enabling targeted applications in drug delivery, biosensing, and imaging.
Internalizing Antibody Production and QC Service
- Internalizing antibodies are a class of therapeutic agents that, upon binding to their target antigen, are internalized into cells via endocytosis. Creative Biolabs offers a comprehensive service to develop and produce internalizing antibodies with enhanced properties, such as increased cellular uptake and improved therapeutic efficacy.
Advanced Eukaryotic Expression System
Eukaryotic expression systems, such as mammalian cell lines, are essential for producing functional antibodies. These systems offer the cellular machinery to perform complex post-translational modifications, ensuring correct protein folding, assembly, and biological activity. Additionally, they enable high-level expression and scalability, making them ideal for the large-scale production of therapeutic antibodies. Here we provide several well-validated eukaryotic expression systems for global customers to design for your meaningful projects:
Benefits for You
- Competent research team
- High-standard facilities
- Flexible production scale
- Reliable antibody quality
- Efficient delivery timeline
Creative Biolabs stands at the forefront of antibody innovation, committed to enhancing the development and production of high-quality antibodies. Our team continuously refines the methodologies to guarantee efficient and dependable outcomes for your functional antibody initiatives. If you're in search of a trustworthy collaborator for your antibody projects, please feel free to get in touch with us to customize your meaningful functional antibody production projects. With our extensive knowledge in antibody engineering, expression, and characterization, paired with a steadfast dedication to quality and groundbreaking solutions, we are here to support your research and therapeutic aspirations.
Reference
- Abdeldaim, Dalia T., and Katharina Schindowski. "Fc-engineered therapeutic antibodies: recent advances and future directions." Pharmaceutics 15.10 (2023): 2402. Distributed under Open Access License CC BY 4.0, without modification.
For research use only. Not intended for any clinical use.
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