Antibody-Extracellular Vesicle Development Solutions

At Creative Biolabs, our outstanding Antibody-extracellular vesicles (EVs) service platform and vast knowledge in the field make us the top choice for researchers and companies looking to advance their studies in this area.

Platform

Antibody-EVs can be used as a tool for targeted drug delivery, as they can specifically target and deliver antibodies to specific cells or tissues. As a result, Creative Biolabs offers antibody-EV services for our clients seeking to explore the potential of EVs in their studies. Antibody-EVs service allows for the isolation, characterization, and functional analysis of these important nanoparticles. Our services can provide a perfect combination of quality, accuracy, and cost-efficiency. Whether you need assistance with experimental design, sample preparation, or data analysis, we are here to help every step of the way.

Fig.1 Antibody-EVs Production Process.^1,3

Services

At Creative Biolabs, our antibody-EV services offer a seamless solution for the design, construction, and verification of EVs loaded with specific antibodies. With the increasing interest in EVs as promising tools for drug delivery, diagnostics, and therapeutics, our services provide a versatile platform to harness the power of EVs in a targeted and efficient manner.

Step 1: Antibody Selection and Modification

Our service starts with the selection of high-affinity antibodies targeting specific extracellular vesicle markers. We work closely with clients to choose the most suitable antibodies and modify them for optimal vesicle binding and uptake.

Step 2: Extracellular Vesicle Isolation and Production

Once the antibodies are optimized, we isolate extracellular vesicles from various biological samples and produce customized vesicle populations for specific applications. Our production process ensures high purity and yield of vesicles for downstream experiments.

Step 3: Validation of Antibody-Vesicle Interactions

To ensure the specific binding and uptake of vesicles by target cells, we conduct rigorous validation experiments using a combination of biological assays and imaging techniques. Our validation process confirms the efficacy of the antibody-vesicle constructs for downstream functional studies.

Step 4: Quality control of Antibody-Vesicle Products

Quality control is of utmost importance to us, and we conduct rigorous verification assays to ensure the functionality and integrity of our antibody EVs. Our team employs a variety of assays, including flow cytometry, ELISA, and western blotting, to confirm the presence and activity of the antibodies within the EVs. This comprehensive verification process guarantees the reliability and performance of our antibody-EV products.

Fig.2 The Responses Analysis of Spontaneous Germinal Center B cell EVs in Cγ1CD63-emGFP Nba2 Lupus-prone Mice.^2,3

Advantages

Creative Biolabs is backed by a strong foundation of scientific knowledge and expertise, ensuring that you receive high-quality and reliable results for your research needs. Up to now, we have proven the potential of antibody-EVs in various applications, including targeted drug delivery, immune modulation, and cancer therapy. Meanwhile, our recent advances in EV isolation and engineering techniques have made it easier to produce antibody EVs using a lipid-based approach. Overall, whether you are studying the basic biology of extracellular vesicles or exploring their potential as biomarkers or drug delivery vehicles, we are here to support your research goals.

• Expertise in different vesicle isolation methods, including ultracentrifugation and precipitation;
• Ability to produce vesicles from various cell types and tissues;
• Advanced technologies for vesicle characterization and quantification;
• Expertise in antibody modification techniques for enhanced vesicle targeting;
• Cost-effective solutions without compromising on quality.

Extracellular vesicles play a crucial role in intercellular communication, and Creative Biolabs can help you accurately study and analyze these vesicles with the use of antibodies. Interested in learning more about how our antibody-extracellular vesicle-related services can advance your research? Please contact us to inquire about our services and place an order. We look forward to working with you to accelerate your research in this exciting and rapidly evolving field.

References

1. Wiklander, Oscar PB, et al. "Antibody-displaying extracellular vesicles for targeted cancer therapy." Nature Biomedical Engineering (2024): 1-16.
2. Rival, Claudia, et al. "B cells secrete functional antigen-specific IgG antibodies on extracellular vesicles." Scientific Reports 14.1 (2024): 16970.
3. under Open Access License CC BY 4.0, without modification.

For research use only. Not intended for any clinical use.