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SPAG9
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Group enriched (neutrophil, basophil)
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:19644450). The homodimer interacts with ARF6, forming a heterotetramer (PubMed:19644450). Homooligomer (PubMed:19644450). Interacts with MAX, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4 (By similarity). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (By similarity). Interacts with NFKB1 (PubMed:14743216). Interacts with PIP4P1 (PubMed:29146937). Interacts with PIKFYVE (By similarity). [Isoform 5]: Interacts with MAPK8, MAPK9, MAPK10.
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