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ZNF346
Anti-ZNF346 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- AbPlus™ Anti-ZNF346 Magnetic Beads (VS-0724-YC126) (VS-0724-YC126)
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- Target: ZNF346
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Astrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.
Molecular function
RNA-binding
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