Recombinant Anti-FCRL3 Vesicular Antibody, EV Displayed (VS-0425-YC525)
CAT#: VS-0425-YC525
The Recombinant Anti-FCRL3 Vesicular Antibody, EV Displayed (VS-0425-YC525) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FCRL3-expressed cells or tissues. FCRL3 is a protein in the immunoglobulin receptor superfamily, containing motifs that regulate immune system functions. Mutations in FCRL3 are linked to autoimmune diseases such as rheumatoid arthritis.
Gene Expression
Normal Tissue
Figure 1 High expression in appendix
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48022/148749_A_3_2_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48022/148749_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48022/148749_A_8_8.jpg
Normal Tissue
Figure 4 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48022/148749_A_4_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (Daudi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160856-FCRL3
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FCRL3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fc receptor like 3
- Biological Process
- Fertilization
- Molecular Function
- Receptor
- Introduction
- This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- Alternative Names
- CD307c, FCRH3, IFGP3, IRTA3, SPAP2, SPAP2a, SPAP2b, SPAP2c, SPAP2d, SPAP2e
- Gene ID
- 115352
- UniProt ID
- Q96P31
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Datasheet
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COA
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See other products for "FCRL3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3110z | Mouse Anti-FCRL3 Recombinant Antibody (clone 18D11) | WB, IP, IF, ELISA | Mouse IgM, κ |
| HPAB-1150-FY | Human Anti-FCRL3 Recombinant Antibody (clone E3) | ELISA, FC | Human IgG |
| HPAB-1151-FY | Human Anti-FCRL3 Recombinant Antibody (clone E9) | ELISA, FC | Human IgG |
| MOB-013YJL | Mouse Anti-FCRL3 Recombinant Antibody (clone CB56YJ) | FC, ELISA | Mouse IgG1 |
| MOB-068YJL | Mouse Anti-FCRL3 Recombinant Antibody (clone CBF828) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1150-FY-F(E) | Human Anti-FCRL3 Recombinant Antibody (clone E3); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-1151-FY-F(E) | Human Anti-FCRL3 Recombinant Antibody (clone E9); scFv Fragment | ELISA, FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1150-FY-S(P) | Human Anti-FCRL3 Recombinant Antibody (clone E3); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-1151-FY-S(P) | Human Anti-FCRL3 Recombinant Antibody (clone E9); Fab Fragment | ELISA, FC | Humanized Fab |
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