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Anti-CD276 Recombinant Antibody Products

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Functional Antibody Products Formats

Creative Biolabs provides comprehensive technical support for the CD276 recombinant antibody products, including assistance with experimental design, optimization of assay conditions, troubleshooting, and data analysis. Our team of experienced scientists is available to answer any inquiries regarding product usage, storage, and handling, ensuring that researchers can effectively utilize the antibody for their experiments. Additionally, we also offer validation data and recommended protocols to aid researchers in obtaining reliable and reproducible results with the antibody.

CD276: A Versatile and Important Target for Disease

The CD276 protein (B7-H3) is a promising target for disease treatment due to its roles in regulating the immune response and promoting tumor growth. When CD276 binds to its receptor on T cells, it can inhibit their activity and suppress the immune response, which can be beneficial in autoimmune diseases where the immune system is overactive. Besides, CD276 is also overexpressed in many types of cancer, where it promotes tumor growth and evasion of the immune system. In these cases, targeting CD276 can help enhance the anti-tumor immune response and inhibit tumor growth.

Anti-CD276 Recombinant Antibody Products

Our anti-CD276 recombinant antibody products are monoclonal antibodies that specifically target and block the CD276 protein. These recombinant antibodies are engineered for increased potency and specificity, making them valuable research tools for studying the role of CD276 in cancer development and potentially for developing targeted cancer therapies. Our list of anti-CD276 recombinant antibody products includes a variety of formulations and conjugation options to suit different experimental needs.

Table 1. Featured anti-CD276 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
HPAB-0049LY Human Anti-CD276 Recombinant Antibody (HPAB-0049LY) Human Human IgG FuncS, ELISA, FC, IHC
HPAB-0234-CN Human Anti-CD276 Recombinant Antibody (HPAB-0234-CN) Human; Mouse Human IgG ELISA, FC, IF
HPAB-0239-CN Human Anti-CD276 Recombinant Antibody (HPAB-0239-CN) Human Human IgG ELISA, FC, IHC
HPAB-0236-CN Mouse Anti-CD276 Recombinant Antibody (HPAB-0236-CN) Human, Cynomolgus Mouse IgG1 IHC, Cyt, Inhib, ELISA, FC
TAB-424CQ Anti-Human CD276 Recombinant Antibody Human Human IgG1 ELISA, IHC, IF, IP, FCM, FunS

Creative Quality Control

The CD276 recombinant antibody products at Creative Biolabs utilizes a stringent quality control process to ensure the highest level of product quality. By maintaining a thorough quality control program, we are able to consistently provide reliable and effective CD276 recombinant antibody products to researchers and clinicians for their immunotherapy and cancer research needs.

Fig.1 SDS-PAGE analysis. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-CD276 antibody
(Cat# HPAB-0234-CN, Creative Biolabs).

Fig.2 SEC-HPLC analysis. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-CD276 antibody (Cat#
HPAB-0236-CN, Creative Biolabs).

Fig.3 ELISA analysis. (Creative Biolabs Original)Fig.3 ELISA analysis of anti-CD276 antibody (Cat#
TAB-424CQ, Creative Biolabs).

Fig.4 WB analysis. (Creative Biolabs Original)Fig.4 WB analysis of anti-CD276 antibody (Cat#
TAB-424CQ, Creative Biolabs).

Customer Reviews

Excellent
Fe***l
Anti-Human CD276 Recombinant Antibody (CAT#: TAB-424CQ)
I have been using the CD276 antibody for my experiments and it has proven to be very reliable and efficient. The antibody is of high quality and I have been able to obtain accurate and reproducible results. I am very pleased with my purchase.
20/Oct/2021 3 Likes
Excellent
T***c
Human Anti-CD276 Recombinant Antibody (HPAB-0049LY) (CAT#: HPAB-0049LY)
I bought the CD276 antibody for my lab work and I am extremely happy with the product. The antibody is very specific and has helped me to obtain excellent results in my experiments. I highly recommend this antibody to anyone in need of a reliable and effective reagent.
20/Feb/2023 1 Likes

Anti-CD276 Recombinant Antibody Production

Our anti-CD276 recombinant antibody production platform utilizes genetically engineered cells to express and secrete antibodies targeting the CD276 protein, allowing for scalable and cost-effective antibody production.

Featured Anti-CD276 Recombinant Antibody Production Platforms

Fig.5 Milligram-scale. (Creative Biolabs Original)Fig.5 Milligram-scale anti-CD276 recombinant antibody production.

Fig.6 Gram-scale. (Creative Biolabs Original)Fig.6 Gram-scale anti-CD276 recombinant antibody production.

Anti-CD276 Recombinant Antibody Modalities

Creative Biolabs is committed to providing researchers with the most comprehensive and cutting-edge high-quality anti-CD276 recombinant antibodies in different formats.

Fig.7 CD276 antibody production and modalities. (Creative Biolabs Original)Fig.7 Full-length anti-CD276 recombinant antibody production and modalities.

Alternative Names

CD276; CD276 Molecule; Costimulatory Molecule; CD276 Antigen; B7 Homolog 3; B7H3; CD276; B7RP-2; 4Ig-CD276

Background

CD276 (CD276 Molecule) is a Protein Coding gene. Diseases associated with CD276 include Neuroblastoma and Acute Cervicitis. Among its related pathways are T Cell Co-Signaling Pathways: Ligand-Receptor Interactions and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include receptor binding.
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Hofbauer cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HaCaT, U-2197)

Interaction

Interacts with TREML2 and this interaction enhances T-cell activation.

More Types Infomation

Public Drug Information Targeting CD276

Table 2. Public drug targeting CD276.

Research phase Company Classification Indications Details
Approved Memorial Sloan-Kettering Cancer Center (Originator);
Y-mAbs Therapeutics. 		Cancer Immunotherapy;
Iodine-Radiolabeled Products;
Murine Monoclonal Antibodies;
Nuclear Imaging Agents;
Radioimmunoconjugates;
Radionuclide Therapy. 		Cancer, metastatic (to meninges);
Cancer, peritoneum;
Cancer, solid tumor;
Ependymoma;
Medulloblastoma;
Neuroblastoma;
Neurologic cancer;
Tumor, desmoplastic small round cell. 		O***b is an iodine-131-labeled analog of the murine monoclonal antibody 8H9 o***b developed at Y-mAbs Therapeutics.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Clinical Drug Information Targeting CD276

Table 3. Therapeutic approaches targeting CD276 in clinical development.

Highest Development Stage Organization Condition Indication
Phase II/III MacroGenics Cancer, prostate (castration-resistant) Treatment of metastatic castration-resistant prostate cancer (mCRPC) progressing after prior androgen receptor axis-targeted therapy (ARAT) and prior taxane-containing chemotherapy
Phase II I-Mab Biopharma Cancer, solid tumor In patients with solid tumors including non-small cell lung cancer and urothelial carcinoma, in combination with pembrolizumab
Phase II Hansoh Pharma Cancer, esophagus Treatment of advanced/metastatic/recurrent esophageal carcinoma relapsed after prior therapy
Phase II Daiichi Sankyo Cancer, lung (small cell) (SCLC) (extensive) Treatment of extensive-stage small cell lung cancer (ES-SCLC) after prior lines of therapy
Phase II MediLink Therapeutics Cancer, prostate (castration-resistant), metastatic Treatment of subjects with metastatic castration-resistant prostate cancer (mCRPC) previously treated with at least one prior line of novel hormone therapy
Phase I/II Shenzhen Genoimmune Medical Institute Cancer, solid tumor In patients with CD276 positive solid tumors that are unresectable, metastatic, progressive or recurrent
Phase I/II Mabwell (Shanghai) Bioscience Cancer, solid tumor Treatment of adult patients with advanced solid tumors
Phase I/II Duality Biologics Cancer, solid tumor Treatment of CD276-expressing unresectable advanced/metastatic solid tumors
Phase I/II Innovent Biologics Cancer, solid tumor Treatment of CD276-expressing solid tumors
Phase I/II Minghui Pharmaceutical Cancer, solid tumor Treatment of advanced or metastatic solid tumors
Phase I/II Takeda Cancer, solid tumor Treatment of patients with unresectable, locally advanced or metastatic cancer failing or intolerant to standard therapies
Phase I University North Carolina, Chapel Hill Cancer, ovary In patients with recurrent ovarian cancer (either epithelial ovarian, peritoneal or fallopian tube) refractory to platinum-based chemotherapy
Phase I Seattle Children's Hospital Neurologic cancer In children and young adults with diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG), and recurrent or refractory central nervous system tumors
Phase I St Jude Children's Research Hospital Cancer, solid tumor In pediatric and young patients (up to 21 years old) with relapsed or refractory CD276+ solid tumors
Phase I Bio-Thera Solutions Cancer, solid tumor In patients with advanced solid tumors
Phase I Innovent Biologics Cancer, solid tumor In patients with unresectable, locally advanced or metastatic solid tumors, such as non-small-cell lung cancer, head and neck squamous cell carcinoma and RAS-wildtype colorectal cancer
Phase I AbbVie Cancer, solid tumor Alone or in combination with paclitaxel or docetaxel in adult patients with malignant solid tumors, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC) and breast cancer
Phase I PersonGen Biomedicine (Suzhou) Cancer, solid tumor In patients with CD276-positive advanced solid tumors, including malignant melanoma, lung cancer or colorectal cancer
Phase I PersonGen Biomedicine (Suzhou) Acute myeloid leukemia For the treatment of adult patients with relapsed/refractory acute myeloid leukemia
Phase I Xencor Cancer, solid tumor In combination with pembrolizumab in advanced solid tumors including head and neck squamous cell carcinoma, melanoma excluding uveal melanoma, non-small cell lung cancer, urothelial carcinoma, clear cell renal cell carcinoma, castration-resistant prostate cancer, epithelial ovarian cancer, triple-negative breast cancer, and colorectal cancer
Discontinued Daiichi Sankyo Cancer, solid tumor Advanced solid tumor that is refractory to standard treatment, or for which no standard treatment is available
Discontinued MacroGenics Cancer, solid tumor In patients with unresectable or metastatic CD276-expressing neoplasms, as a monotherapy or in combination with MGA-012
IND Filed Innolake Biopharm Cancer, solid tumor
Preclinical Y-mAbs Therapeutics Cancer, solid tumor
Preclinical Daiichi Sankyo Cancer, breast PET/MRI imaging
Preclinical Antengene Cancer, solid tumor
Preclinical BioAtla Cancer, solid tumor
Preclinical BeiGene Cancer, solid tumor treatment of advanced/metastatic solid tumors, alone or in combination with tislelizumab
Preclinical GT Biopharma Cancer, solid tumor
Preclinical Innovent Biologics Cancer, solid tumor
Preclinical Intocell Cancer
Preclinical First People's Hospital of Lianyungang Cancer, solid tumor
Preclinical MacroGenics Cancer, pancreas

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

With a wide range of options to choose from, Creative Biolabs provide you with the perfect antibody for your needs. Whether you require bulk quantities or small quantities, our team is dedicated to delivering top-notch products with quick shipping and excellent customer service. Contact us now to learn more about our anti-CD276 antibodies and how we can support your research goals.

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