MUC1 & CD2

MUC1 encodes a cell surface glycoprotein that functions as a protective mucin, contributing to the barrier function of epithelial tissues. It is involved in protecting the gastrointestinal, respiratory, and genitourinary tracts from pathogens. MUC1 is also implicated in cancer progression, particularly in breast, lung, and pancreatic cancers, where it can be overexpressed, influencing cell signaling and tumor growth.

CD2 is a surface glycoprotein expressed on T cells, natural killer (NK) cells, and thymocytes. It functions as an adhesion molecule, interacting with ligands such as CD58 (LFA-3) on antigen-presenting cells. This interaction facilitates T cell activation and the formation of the immunological synapse. CD2 also plays a role in signal transduction, contributing to T cell proliferation and cytokine production. Its expression is essential for effective immune responses and has been studied in the context of autoimmune diseases and transplant rejection.