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CHRAC1
Loading...Anti-CHRAC1 Products
- Recombinant Mouse Anti-Human CHRAC1 Antibody (MOB-2128MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer with POLE3; binds to DNA (PubMed:10880450). Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity (PubMed:10880450). Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (PubMed:10880450, PubMed:14759371). Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct (PubMed:10880450, PubMed:12434153, PubMed:14759371).
Molecular function
DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
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