Anti-CYC1 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: ELISA, WB, FC
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- Anti-CYC1 Immunohistochemistry Kit (VS-0325-XY600)
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- Species Reactivity: Human, Mouse
- Target: CYC1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Discover the role of mitochondrial health with Creative Biolabs' premier anti-CYC1 recombinant antibodies. Cytochrome C1 (CYC1) is the nuclear-encoded subunit of Complex III (Cytochrome C1 complex) and is involved in electron transfer and cellular respiration. Creative Biolabs' high-quality anti-CYC1 recombinant antibodies will help you study mitochondrial health, Complex III, and the bioenergetics of disease.
CYC1: The Cytochrome C1 Component of Complex III
Cytochrome C1 (CYC1) is the nuclear-encoded, heme-containing subunit of the Cytochrome C1 complex, III. The CYC1 protein is bound to the inner mitochondrial membrane on the intermembrane space side. The role of CYC1 is to accept electrons from the Rieske iron-sulfur protein subunit, and pass them on to the mobile electron carrier, Cytochrome C (CYCS). In this way, CYC1 forms a functional link between Complex III and Complex IV. CYC1 is required for the stability and function of the whole Complex III enzyme. Therefore, measuring its expression is a reliable way to estimate the total content of Complex III.
Alternative Names
CYC1; Ubiquinol-Cytochrome-C Reductase Complex Cytochrome C1 Subunit; Cytochrome C-1; Cytochrome B-C1 Complex Subunit 4; MC3DN6; Cytochrome C1, Heme Protein, Mitochondrial; Complex III Subunit 4; UQCR4
Background
CYC1 (Cytochrome C1) is a Protein Coding gene. Diseases associated with CYC1 include Mitochondrial Complex III Deficiency, Nuclear Type 6 and Isolated Complex III Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Distal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (PC-3)
Interaction
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (PubMed:28844695).
Molecular function
Translocase
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Anti-CYC1 rAb Products
Creative Biolabs' anti-CYC1 recombinant antibodies are produced for top-tier sensitivity and performance. Each batch is validated to specifically detect CYC1 protein within mitochondrial fractions. The anti-CYC1 rAbs are optimized for applications such as Western Blot to measure the level of Complex III, and for IHC, our recombinant antibodies provide the quality and specificity needed for high-level metabolic studies.
Table 1. Featured anti-CYC1 recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOB-3822z | Mouse Anti-CYC1 Recombinant Antibody (clone 22D6) | Human | Mouse IgG1, κ | WB, IP, IF, ELISA |
| VS4-WK134 | Mouse Anti-CYC1 Recombinant Antibody (clone 27E12D11) | Human, Mouse | Mouse IgG1 | ELISA, WB, FC |
Customer Reviews
Excellent
Dav**idMouse Anti-CYC1 Recombinant Antibody (clone 22D6)
The anti-CYC1 antibody from Creative Biolabs was the one I needed for my research. I used it for a Western blot of mitochondrial fractions, and it showed that it is clearly expressed in all of our controls.
11/Oct/2024
rAb Production
Creative Biolabs is committed to advancing the emerging and specialized field of mitochondrial research. We leverage cutting-edge production platforms and workflows to ensure that our anti-CYC1 recombinant antibodies are produced in systems that have been optimized to ensure high specificity and activity, and recognize the native protein.
Featured Anti-CYC1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CYC1 recombinant antibody production.
Fig.2 Gram-scale anti-CYC1 recombinant antibody production.
rAb Modalities
Creative Biolabs is on a mission to enable science breakthroughs by developing the most flexible antibody solutions possible. Our anti-CYC1 recombinant antibodies are available in a variety of modalities to meet your needs and can be customized for your specific experimental applications.
Fig.3 Full-length anti-CYC1 recombinant antibody production and modalities.
Accelerate mitochondrial research with Creative Biolabs' anti-CYC1 recombinant antibodies, trusted by experts for their quality and consistency. Experience top-tier validation and robust performance on this crucial Complex III subunit with Creative Biolabs. Contact one of our antibody specialists today.