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DEFB1
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For Research Use Only. Not For Clinical Use.
Background
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Protein class
Transporters
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Distal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Monomer (PubMed:23938203). Homodimer (PubMed:23938203).
Molecular function
Antibiotic, Antimicrobial, Defensin
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