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IFITM2

Anti-IFITM2 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Anti-IFITM2 Immunohistochemistry Kit (VS-0325-XY1099)
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- Species Reactivity: Human, Mouse
- Target: IFITM2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (NK-cells, Adipocytes)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (fHDF/TERT166, HHSteC, HMC-1, HSkMC, NB-4, U-937)
Interaction
Interacts with CD81.
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