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RBMXL2

Anti-RBMXL2 Products
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
- Anti-RBMXL2 Immunohistochemistry Kit (VS-0525-XY6043)
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- Species Reactivity: Human
- Target: RBMXL2
- Application: IHC
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: ICC/IF, IP, WB
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For Research Use Only. Not For Clinical Use.
Background
This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility.
Predicted location
Intracellular
Single cell type specificity
Group enriched (Spermatocytes, Late spermatids, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Molecular function
Ribonucleoprotein, RNA-binding
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