A*0201/Human PAP-3 (ILLWQPIPV) MHC Tetramer
CAT#: MHC-LC785
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PAP-3-derived peptide of ILLWQPIPV sequence covering 135-143 and A*0201 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*0201
- Class
- Class I
- MHC Species
- Human
- Antigen
- PAP-3
- Antigen Species
- Human
- Peptide
- ILLWQPIPV
- Range
- 135-143
- Application
- FCM
Target
- Antigen Introduction
- Purple acid phosphatases (PAPs) are metalloenzymes that hydrolyse phosphate esters and anhydrides under acidic condition. In their oxidised form, PAPs in solution are purple in colour. This is due to the presence of a dinuclear iron centre, to which a tyrosine residue is connected via a charge transfer. This metallic centre is composed of Fe3+ and M, where M is Fe3+, Zn2+, Mg2+ or Mn2+. The conserved Fe3+ is stabilised in the ferric form, whereas M may undergo reduction. Upon treatment with mild reductants, PAPs are converted to their enzymatically active, pink form. Treatment with strong reducing agents dissociates the metallic ions, and renders the enzyme colourless and inactive.
- Alternative Names
- PAP3; Purple acid phosphatase 3; ATPAP3; F10B6.10; F10B6_10; purple acid phosphatase 3
- Gene ID
- 838035
- UniProt ID
- A0A178W4D1
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