APC-A*02:01/Human HA-2 (YIGEVLVSV) MHC Tetramer
CAT#: MHC-LC687
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HA-2-derived peptide of YIGEVLVSV sequence covering 41-49 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21252/1961_E1_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21252/48056_B_8_5.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21252/48056_B_6_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21252/48056_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HDLM-2, HEL, HL-60, JURKAT, MOLT-4, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136286-MYO1G
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- HA-2
- Antigen Species
- Human
- Peptide
- YIGEVLVSV
- Range
- 41-49
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- Minor histocompatibility antigen (a.k.a. MHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). Minor histocompatibility antigens (MiHAs) are diverse, short segments of proteins and are referred to as peptides . These peptides are normally around 9-12 amino acids in length and are bound to both the major histcompatibility complex (MHC) class I and class II proteins. Peptide sequences can differ among individuals and these differences arise from SNPs in the coding region of genes, gene deletions, frameshift mutations, or insertions. About a third of the characterized MiHAs come from the Y chromosome. The proteins are composed of a single immunogenic HLA allele. Prior to becoming a short peptide sequence, the proteins expressed by these polymorphic or diverse genes need to be digested in the proteasome into shorter peptides. These endogenous or self peptides are then transported into the endoplasmic reticulum with a peptide transporter pump called TAP where they encounter and bind to the MHC class I molecule. In contrast, proteins from outside cell is internalized and then binds to MHC class II molecule. These antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells.
- Alternative Names
- MYO1G; myosin IG; HA2; MHAG; HLA-HA2
- Gene ID
- 64005
- UniProt ID
- B0I1T2
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC686 | PE-A*02:01/Human HA-2 (YIGEVLVSV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1435 | Anti-MYO1G Immunohistochemistry Kit | IHC |
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