APC-B*53:01/HIV-2 gag (TPYDINQML) MHC Tetramer

CAT#: MHC-LC1074

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HIV-2 gag peptide of TPYDINQML and B*53:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Specifications

  • Allele
  • B*53:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • HIV-2 gag
  • Antigen Species
  • HIV-2
  • Peptide
  • TPYDINQML
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • HIV-2 is closely related to simian immunodeficiency virus endemic in sooty mangabeys (Cercocebus atys atys) (SIVsmm), a monkey species inhabiting the forests of Littoral West Africa. Phylogenetic analyses show that the virus most closely related to the two strains of HIV-2 which spread considerably in humans (HIV-2 groups A and B) is the SIVsmm found in the sooty mangabeys of the Tai forest, in western Ivory Coast.
  • Alternative Names
  • HIV-2 gag; Human immunodeficiency virus 2 gag glycoprotein
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Breast cancer biomarkers at key points during disease progression
Specific HIV-2 Gag Detection
This APC-conjugated tetramer was effective for identifying human CD8 T cells specific to the HIV-2 gag peptide TPYDINQML. The B*53:01 restriction worked well, and we obtained specific staining in our viral research.
Breast cancer biomarkers at key points during disease progression
Reliable Viral Antigen Tool
We successfully used this product to detect T cells targeting the viral gag protein. The tetramer was stable and provided consistent flow cytometry data, supporting our analysis of immune responses to HIV-2.

Q&As

  1. Which HIV-2 peptide does this tetramer present?

    A: This tetramer presents the HIV-2 gag peptide with the sequence TPYDINQML. It is complexed with the human HLA-B*53:01 molecule for the detection of specific T cells.

  2. What is the fluorophore conjugated to this product?

    A: This MHC tetramer is conjugated with Allophycocyanin (APC). It is suitable for flow cytometry applications to analyze individual antigen-specific CD8 T cells reacting to HIV-2.

View the frequently asked questions answered by Creative Biolabs Support.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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