Mouse Anti-BACE1 Recombinant Antibody (HPAB-0285-YC)
CAT#: HPAB-0285-YC
This product is a recombinant mouse antibody that recognizes BACE1. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/952_G12_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows cytoplasmic positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_1_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/947_G12_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_B_7_5.jpg
Normal Tissue
Figure 5 Hippocampus
Glial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_B_8_6.jpg
Normal Tissue
Figure 6 Colon
Glandular cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_9_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_9_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_5_6.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16358/35706_A_7_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186318-BACE1
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Specifications
- Immunogen
- The N-terminal cysteine-containing neoepitope peptide (Cys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Lys-Met) was mixed to mcKLH
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human BACE1
- Species Reactivity
- Human
- Applications
- ELISA, FuncS
- Related Disease
- Alzheimer's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- See the COA
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Beta-Site APP-Cleaving Enzyme 1; Membrane-Associated Aspartic Protease 2; Beta-Site APP Cleaving Enzyme 1; Aspartyl Protease 2; EC 3.4.23.46; Memapsin-2; Asp 2; BACE; ASP2; Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme; Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1; Transmembrane Aspartic Proteinase Asp2; Beta-Secretase 1 Precursor Variant 1; Beta-Site APP-Cleaving Enzyme; APP Beta-Secretase; EC 3.4.23; KIAA1149; HSPC104
- Gene ID
- 23621
- UniProt ID
- P56817
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2939z | Mouse Anti-BACE1 Recombinant Antibody (clone 18H11) | WB, ELISA, FC, ICC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-405 | Human Anti-BACE1 Recombinant Antibody; Fab Fragment (PFBL-405) | ELISA, Block, Neut | Human Fab |
| HPAB-0285-YC-F(E) | Mouse Anti-BACE1 Recombinant Antibody; Fab Fragment (HPAB-0285-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0672-CN-F(E) | Mouse Anti-BACE1 Recombinant Antibody (clone M2-1003); Fab Fragment | ELISA, FC, IHC, Neut | Mouse Fab |
| HPAB-0673-CN-F(E) | Mouse Anti-BACE1 Recombinant Antibody (clone M2-1000); Fab Fragment | ELISA, FC, IHC, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-405 | Human Anti-BACE1 Recombinant Antibody; scFv Fragment (PSBL-405) | ELISA, Block | Human scFv |
| HPAB-0285-YC-S(P) | Mouse Anti-BACE1 Recombinant Antibody; scFv Fragment (HPAB-0285-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0672-CN-S(P) | Mouse Anti-BACE1 Recombinant Antibody (clone M2-1003); scFv Fragment | ELISA, FC, IHC, Neut | Mouse scFv |
| HPAB-0673-CN-S(P) | Mouse Anti-BACE1 Recombinant Antibody (clone M2-1000); scFv Fragment | ELISA, FC, IHC, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1153CL | Mouse Anti-BACE1 Recombinant Antibody (TAB-1153CL) | ELISA | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1154CL | Mouse Anti-BACE1 Recombinant Antibody (TAB-1154CL) | WB | Mouse IgG |
| TAB-1155CL | Mouse Anti-BACE1 Recombinant Antibody (TAB-1155CL) | ELISA, Inhib, FuncS | Mouse IgG |
| TAB-1156CL | Mouse Anti-BACE1 Recombinant Antibody (TAB-1156CL) | WB, IP, Inhib | Mouse IgG |
| TAB-1153CL-S(P) | Mouse Anti-BACE1 Recombinant Antibody; scFv Fragment (TAB-1153CL-S(P)) | ELISA | Mouse scFv |
| TAB-1154CL-S(P) | Mouse Anti-BACE1 Recombinant Antibody; scFv Fragment (TAB-1154CL-S(P)) | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-036CQ | Mouse Anti-BACE1 Recombinant Antibody (clone CBL278) | ELISA, IP, Neut | Mouse IgG1 |
| NEUT-037CQ | Mouse Anti-BACE1 Recombinant Antibody (clone CBL696) | IP, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY45 | Mouse Anti-NHP BACE1 Recombinant Antibody (clone 3C1C3) | WB, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC546 | Recombinant Anti-BACE1 Vesicular Antibody, EV Displayed (VS-0425-YC546) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY676 | Anti-BACE1 Immunohistochemistry Kit | IHC | |
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