Recombinant Human Antibody (C1-28) is capable of binding to HIV-1 Nef134-10(2F), expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 Nef134-10(2F) mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 Nef134-10(2F) proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Cytolytic activities of HLA-A24-restricted Nef134-10-specific CTL clones derived from HLA-A24-positive HIV-1-infected patients.
Clones C1-28 killed HLA-A24-positive target cells pulsed with log-fold dilutions of Nef134-10 peptides, Nef134-10(wt); blue, Nef134-10(2F); red. The effector-versus-target ratio was 5:1.
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